Mucoadhesive microspheres

Gavini E, Rassu G, Sanna V, Cossu M, Giunchedi P (2005) Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide in-vitro/ex-vivo studies. J Pharm Pharmacol 57 287-294. 

S. Harikarnpakdee, V. Lipipun, N. Sutanthavibul, and G. C. Ritthidei. Spray-dried mucoadhesive microspheres Preparation and transport through nasal cell mono-layer. AAPS PharmSciTech 7 E12 (2006). 

FIG. 3. Experimental setup to study the intestinal transit of mucoadhesive microspheres in a chronically isolated loop. (Adapted from Ref 21.)... 

Akiyama, Y., Nagahara, N., Kashihara, T., Hirai, S., and Toguchi, H., In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative, Pharm. Res., 12 397-405... 

Vidgren, P, Vidgren, M., Arppe, J., Hakuli, T., Laine, E., and Paronen, P. (1992), In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration, Drug Dev. Ind. Pharm., 18, 581-597. 

Has i ek, C., Gontil, N., and Erk, N. (2003), Mucoadhesive microspheres containing gentamicin sulfate for nasal administration Preparation and in vitro characterisation,... 

El-Shafy, M. A., Kellaway, I. W., Taylor, G, and Dickinson, P. A. (2000), Improved nasal bioavailability of FITC-dextran (Mw 4300) from mucoadhesive microspheres in rabbits, J. Drug Target., 7, 355-361. 

Mikos and Peppas described the flow channel to measure the bioadhesion of polymer microparticles on mucin gels. Later Lehr et al. ° used an in situ loop model in the rat for the investigation of mucoadhesive microspheres (Fig. 3). They concluded that this approach allowed the study of the transit of particles. Another technique to study the mucoadhesive properties of microspheres is the electrobalance method, as... 

Albertini, B., Passerini, N., Sabatino, M., Di Franco, P, Vitali, B., Brigidi, P., and L. Rodriguez. Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate. Eur J Pharm Sci, 36 (2009) 591-601. 

Shadab, Ahuja A, Khar RK, Baboota S, Chuttani K, Mishra AK et al. Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive microspheres Formulation and evaluation. Drug Delivery. May 2011 18(4) 255-264. PubMed PMID 21110695. 

S wain S, Meher D, Patra CN, Sruti J, Dinda SC, Rao ME. Design and characterization of sustained release mucoadhesive microspheres of tolterodine tartrate. Current Drug Delivery. August 2013 10(4) 413—426. PubMed PMID 23215776. 

Patel JK, Chavda JR. Formulation and evaluation of stomach-specific amoxicillin-loaded carbopol-934P mucoadhesive microspheres for anti-Helicobacter pylori therapy.. Journal of Microencapsulation. June 2009 26(4) 365-376. PubMed PMID 18720199. 

G. Rajput, F. Majmudar, J. Patel, R. Thakor, and N. Rajgor, Stomach-specific mucoadhesive microsphere as a controlled drug delivery system. Systematic Reviews in Pharmacy, 1 (1), 70,2010. 

Mucoadhesive microspheres or nanospheres can be used to overcome these restrictions. 

Abbas Z, Marihal S. Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration Formulation optimization using factorial design, characterization, and in vitro evaluation. J Pharm Bioall Sci. 6 (4) 267-77, 2014. 

Patil, Sanjay B., Krutika K. Sawant Development, optimization and in vitro evaluation of alginate mucoadhesive microspheres of carvedilol for nasal delivery. Journal of Microencapsulation 26, no. 5 (2009), 432-443. 

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