Microparticles products

Bleich, J., Mueller, B. W., and Wassmus, W. Aerosol solvent extraction system A new microparticle production technique. Int. J. Pharm. 97 111-117, 1993. 

WaBnus, W., Bleich, J., and Muller, B. W. (1991), Microparticle production by using supercritical gases, Clin. Pharmacol., 13, 367. 

Reverchon E, De Marco I, Della Porta G. Rifampicin microparticles production by supercritical antisolvent precipitation. Int J Pharm 2002 243 83-91. 

RepkaMA, Langley NA, DiNunzio J (2013) Melt extrusion materials, technology and drug product design. AAPS advances in the pharmaceutical sciences series, vol 9. Springer, New York Reverchon E, De Marco I, Delia Porta G (2002) Rifampicin microparticles production by supercritical antisolvent precipitation. Int J Pharm 243(l-2) 83-91... 

Reverchon, E., Adami, R., Caputo, G., De Marco, I. (2008). Spherical microparticles production by supercritical antisolvent precipitation Interpretation of results. The Journal of... 

Starch is a polysaccharide found in many plant species. Com and potatoes are two common sources of industrial starch. The composition of starch varies somewhat in terms of the amount of branching of the polymer chains (11). Its principal use as a flocculant is in the Bayer process for extracting aluminum from bauxite ore. The digestion of bauxite in sodium hydroxide solution produces a suspension of finely divided iron minerals and siUcates, called red mud, in a highly alkaline Hquor. Starch is used to settle the red mud so that relatively pure alumina can be produced from the clarified Hquor. It has been largely replaced by acryHc acid and acrylamide-based (11,12) polymers, although a number of plants stiH add some starch in addition to synthetic polymers to reduce the level of residual suspended soHds in the Hquor. Starch [9005-25-8] can be modified with various reagents to produce semisynthetic polymers. The principal one of these is cationic starch, which is used as a retention aid in paper production as a component of a dual system (13,14) or a microparticle system (15). 

Polymeric microparticles have been studied and developed for several years. Their contribution in the pharmacy field is of utmost importance in order to improve the efficiency of oral delivery of drugs. As drug carriers, polymer-based microparticles may avoid the early degradation of active molecules in undesirable sites of the gastrointestinal tract, mask unpleasant taste of drugs, reduce doses and side effects and improve bioavailability. Also, they allow the production of site-specific drug targeting, which consists of a suitable approach for the delivery of active molecules into desired tissues or cells in order to increase their efficiency. 

The influence of the lipophilic external phase on the production of xylan-based microparticles by interfacial cross-linking polymerization has been investigated (Nagashima et al., 2008). Three different external phases were investigated a 1 4 (v/v) chloroform cyclohexane mixture, soybean oil, and a medium chain triglyceride, with viscosities below 1, 24, and 52 cP, respectively. It was observed that the use of these different lipid phases results in different macroscopic and microscopic aspects of the system (Figure 10). 

Raffin, R. P., Jornada, D. S., Re, M. L, Pohimann, A. R. Guterres, S. S. (2006). Sodium pantoprazole-loaded enteric microparticles prepared by spray drying Effect of the scale of production and process validation. International Journal of Pharmaceutics, Vol. 324,1, (October 2006), pp. (10-18), ISSN 0378-5173... 

However, with respect to other delivery systems, microparticles could maintain their physicochemical characteristics unaltered for long periods, allowing long-term storage they can be administered through different ways (orally, intramuscularly, or subcutaneously), depending on their composition and they are suitable for industrial production [23,24],... 

Rogerson, C., The Design and Production of Microparticles for Inhalation, Proc. Recent Advances in Dry Powder Inhalers, London, 1996. 

The SWV of microparticles of the lipid-lowering drag simvastatin is shown in Fig. 3.8 [188]. The electrode reaction is totally irreversible, as indicated by the backward component of the response. The net peak potential is a linear function of the logarithm of SW frequency, as can be seen in Fig. 3.9. From the slope of this relationship (79 mV/d.u.) the product an = 0.75 was calculated [188]. These examples show that SWV can be used for the characterization of electrode reactions of microparticles inunobilized on solid electrodes. 

There has long been an interest in micrometer and submicrometer-size aerocolloidal particles because of their undesirable features as air pollutants, and much of the research on such particles during the past few decades has been stimulated by these objectionable aspects of microparticles. Although pigments such at Ti02 particles have been produced via aerosol technology for many years, a recent surge of interest in the production of fine particles for... 

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