Dual CD system

FIGURE 3.5 CE strategy proposed in Matthijs et al. [30] including dual CD systems. Steps to be performed in optimizations 1, 2, and 3, see Figure 3.4b-d. (Reprinted from Matthijs, N. et al. An. Chim. Acta 2004, 525, 247-263. Copyright (2004). With permission from Elsevier.)... 

Dual cyclodextrin systems can be developed to provide impressive selectivity of separation [30—32], A typical recipe uses 0.5-1 mM of a charged CD and 5-10 mM of a neutral CD. The development of a dual-CD system chiral separation of secondary amine drug substances is illustrated in Figure 4 using various blends of CDs. A complete separation is only found in run (d), where the buffer contained 5 mM of a neutral and 1 mM of a charged CD. 

Lipka E, Danel C, Yous S, Bonte JP, Vaccher C. Dual CD system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoni-nergic ligands. Electrophoresis 2010 31 1529-1532. 

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