Microfluidic Systems for High-Throughput Screening

In a wider sense, the Hantzsch synthesis is a further example for evaluating the potenhal of microfluidic systems for high-throughput screening [9]. 

Microfluidic Devices in Tissue Engineering Microfluidic Systems for High-Throughput Screening... 

Microfluidic Systems for High-Throughput Screening, Fig. 2 A schematic visualization of the UHTSS configuration (Aurora Biosciences, San Diego, CA, USA) a working compound solution store, an automated... 

Microfluidic Systems for High-Throughput Screening, Fig. 3 Novel microfluidic surface patterning (a) nanofoundation probe (NFP) (i. writing mechanism of the NFP device, a molecular ink fed from the reservoir forms a liquid-air interface at the annular aperture of the volcano tip. Molecules are transferred by diffusion from the interface to a substrate and a water meniscus is formed by capillary condensation ii. ink from the reservoir is... 

Microfluidic Systems for High-Throughput Screen- micromosaic immunoassay to localize surface-binding ing. Fig. 4 A new concept of surface pattering based on events taking place in the independent microchannels of a microfluidic network (pFN) (a) principle of a pFN (b) combinatorial micromosaic immunoassay used... 

Microfluidic Systems for High-Throughput Screen- channel, (b) a sieve valve having a square-profiled fluidic... 

Microfluidic Systems for High-Throughput Screen- [12] and (b) a micro cell sorter chip with integrated holding, Fig. 7 High-throughput cell sorters (a) an optically ing/culturing chamber [13] (see entry Flow Cytometer switched microfluidic fluorescence-activated cell sorter Lab-on-a-Chip Devices )... 

Microfluidic Systems for High-Throughput Screening, Fig. 8 Droplet-based microfluidic systems (a) droplets formed with microfluidic channels (an enzymatic assay for a single mast cell within a droplet. Hi. bright-fleld images ii., iv. fluorescence images [14]) and (b) in vitro evolution of proteins in a microfluidic channels... 

GlaxoSmithKline Pharmaceuticals in Harlow, UK, performed the Hantzsch synthesis of 2-bromo-4 -methylacetophenone and l-acetyl-2-thiourea in NMP (N-methyl-2-pyrrolidone) using a microchip reactor under EOF conditions [10] (for EOF see [11]) [10]. This is claimed to be the first example of a heated organic reaction performed on a glass chip reactor under electroosmotic flow control, whereas only room temperature reactions were made earlier. In a wider scope, the Hantzsch synthesis is a further example to evaluate the potential of microfluidic systems for high-throughput screening. 

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