Nebulizers microflow

A further miniaturization of solution introduction into ICP-MS allows the analysis of nanolitre sample volumes so that 100% transport efficiency is achieved and dead volume is minimized using nanovolume ( 50 nl) flow injection together with a total consumption nebulizer operating at uptake rates significantly below the 10p,lmin 1 level. The microflow nebulizer (DS 5 developed... 

Figure 5.19 Experimental arrangement of nanoflow injection in ICP-MS using the microflow nebulizer DS 5 with spray chamber together with a nanoinjection ventile a) schematic and (b) photograph, (j. S. Becker, Trends in Anal. Chem., 24, 243 (2005). Reproduced by permission of Elsevier.)...

On line isotope dilution in LA-ICP-MS using a microflow nebulizer (DS-5) inserted in the laser ablation chamber (experimental setup is shown in Figure 6.23) for the analysis of uranium in NIST glass standard reference material (SRM) 612 and NIST apple leaves SRM 1515 is described by Pickhardt et al In the analysis of SRMs, firstly the isotope ratio in the standard was... 

KEYWORDS inductively coupled plasma mass spectrometry, organic solvents, microflow nebulizer, trace and ultra trace metals in crude oils, maltenes, and asphaltenes... 

Maltenes, 51 Mercury, 181, 196, 207 volatile, 181 Microflow nebulizer, 51 Microwave digestion, 33 Monochromatic wavelength dispersive x-ray fluorescence, 116... 

In spite of all the advantages mentioned above, ETV-ICPMS, the introduction of which 25 years ago was received with great enthusiasm by the analytical community, has failed to become a standard introduction system for ICPMS. Nowadays, its use is mainly restricted to research centers and academia, not only in the field of polymer analysis, but also in every other field. The reason is perhaps related to the more recent introduction of microflow nebulizers that also show some of the advantages displayed by ETV (low sample consumption, higher analyte introduction efficiency). Moreover, the lack of the general success of ETV can also in part... 

Online isotope dilution technique LA-ICP-MS is proposed as the method of choice for quantitative element mapping and imaging even if no reference materials are available (42). For online solution-based calibration with LA-ICP-MS, a microflow total consumption nebulizer DS-5 (CETAC Technologies, Omaha, NE, USA) was inserted into the laser ablation chamber (21). It is more convenient to use solution-based calibration because such calibration can be performed easily, quickly and in any concentration range for many elements. The application of the online isotope dilution technique in LA-ICP-MS using a microflow nebulizer inserted into the laser ablation chamber to biological standard reference materials (e.g., apple leaves) yielded accurate analyte concentrations (42). 

Pickhardt, C., Izmer, A., Zoriy, M., Schaumloffel, D., Becker, J. S. (2006) Online isotope dilution in laser ablation inductively coupled plasma mass spectrometry using a microflow nebulizer inserted in the laser ablation chamber. Int J Mass Spectrom, 248,136-141. 

Specialized microflow nebulizers coupled with desolvation techniques... 

Specialized Microflow Nebulizers with Desolvation Techniques... 

Microflow or low-flow nebulizers, which were described in greater detail in Chapter 3, are being used more and more for routine applications. The most common ones used in ICP-MS are based on the microconcentric design, which operate at sample flows of 20-500 pL/min. Besides being ideal for small sample volumes, the major benefit of microconcentric nebulizers is that they are more efficient and produce smaller droplets than a conventional nebulizer. In addition, many microflow nebulizers use chemically inert plastic capillaries, which makes them well suited for the analysis of highly corrosive chemicals. This kind of flexibility has made low-flow nebulizers very popular, particularly in the semiconductor industry, where it is essential to analyze high-purity materials using a sample introduction system that is free of contamination." ... 

Microflow nebulizer coupled with a Peltier-cooled spray chamber An... 

Microflow nebulizer with heated spray chamber and Peltier-cooled condenser An example of this design is the Apex inlet system from ESI. This unit includes a microflow nebulizer, heated cyclonic spray chamber (up to 140°C), and a Peltier multipass condenser/cooler (down to -5°C). A number of different spray chamber and nebulizer options and materials are available, depending on the application requirements. Also, the system is available with Teflon or Nafion microporous membrane desolvation, depending on the types of samples being analyzed. Figure 17.12 shows a schematic of the Apex sample inlet system with the ctoss-Aow nebulizer. 

Microflow nebulizer coupled with membrane desolvation An example of this is the Aridus system from Cetac Technologies. The aerosol from the nebulizer is either self-aspirated or pumped into a heated PEA spray chamber (up to 110°C) to maintain the sample in a vapor phase. The sample vapor then enters a heated PTFE membrane desolvation unit, where a coun-... 

FIGURE 17.13 A schematic of the Aridus II microflow nebulizer with membrane desolvation (courtesy of Cetac Technologies). 

Chapter 3 examines one of the most critical areas of the instrument—the sample introduction system. It discusses the basic principles of converting a liquid into a fine-droplet aerosol suitable for ionization in the plasma, and presents an overview of the different types of commercially available nebulizers and spray chambers. Although this chapter briefly touches upon some of the newer sampling components introduced in the past few years, such as microflow nebulizers and aerosol dilution systems, the new breed of desolvating nebulizers, chilled spray chambers, autodilution, and online chemistry systems, are specifically described in Chapter 17. 

Microflow nebulizer with heated spray chamber and Peltier-cooled condenser An example of this design is the Apex inlet system from ESI. This unit includes a microflow nebulizer, heated cyclonic spray chamber (up to 140°C), and a Peltier multipass condenser/cooler (down to -5°C). 

Alvaeez-Liamas G., Fernandez De La Campa M. R., Fernandez Sanchez M. L. and Sanz-Medel A. (2002) Comparison of two CE-ICP-MS interfaces based on microflow nebulizers application to cadmium speciation in metallothioneins using quadrupole and double-focusing mass analyzers,... 

Takenaka, M., Yamada, Y, Yabuki, M., Nakamura, S., and Kozuka, S. (2001) Determination of the ultratrace metallic impurities distribution in silicon wafers by sub-area chemical etching/microflow nebulizer-ICP-MS. Bunseki Kagaku, 50(6), 399-404. 

---