Microarrays influenza virus

FIGURE 3 Examples of virus receptors identified by glycan microarrays. Examples of influenza virus A glycan receptors identified from HMG shotgun array (A), and MVM receptors identified from CFG microarray (B), and the HMG SGM (C). Common motifs for virus recognition are highlighted by boxes. 

Stevens J, Blixt O, Glaser L, Taubenberger JK, Palese P, Paulson JC, Wilson lA. Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Mol Biol 2006 355 1143-1155. 

Whole influenza viruses have also been shown to bind to carbohydrate microarrays in a preliminary study (24). The observed binding pattern matched with the previous determined binding preferences. Influenza virus is one of the most dangerous infectious pathogens leading to hundred thousands of deaths per year worldwide... 

Delehanty and Ligler [5] used an antibody microarray system with continuous fluid flow to detect microbial toxins and simultaneously detected both cholera toxin and staphylococcal enterotoxin at a detection level as low as 8 and 4 ng/ml, respectively, within 15 min. Yang et al. [6] developed a device for detecting and genotyping influenza A viruses. Construction of the device utilizes solid-state electronics microfabiicated in silicon and glass, deposition of resistive heaters for thermal... 

Childs RA, Palma AS, Wharton S, Matrosovich T, Liu Y, Chai W, Campanero-Rhodes MA, Zhang Y, Eickmann M, Kiso M et al. (2009) Receptor-binding specificity of pandemic influenza A (HlNl) 2009 virus determined by carbohydrate microarray. Nat Biotechnol 27 797-799... 

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