Micro reactor Technology

The PAMIR study predicts fine chemicals as one of the first fields where commercialization of micro-reactor technology will start [241, 337]. The small quantities, sometimes only in the kilogram range, and the large margins make the substitution of existing processes by micro reactors attractive. Currently, we can see the first signs of this, e.g. the work of Merck, Siemens-Axiva, Clariant and others. 

C., d Ortona, U., Falk, L., MiRTH-e Micro-reactor technology for hydrogen and electricity, in Matlosz, M., Ehreeld, W, Baselt, J. P. (Eds.), Microreaction Technology - IMRET 5 Proc. of the 5th International Conference on Microreaction Technology, pp. 368-375, Springer-Verlag, Berlin (2001). 

D. O., Warrington, B. H., Wong, S. Y. F., The preparation of a series cf nitrostilbene ester compounds using micro-reactor technology. Analyst 126 (2001) 7-10. 

The reduction of reaction times by changing from batch processing to micro-reactor technology is a major driver [8]. Typical Michael batch additions require hours to be completed. 

The worst hazard scenarios (excessive temperature and pressure rise accompanied by emission of toxic substances) must be worked out based upon calorimetric measurements (e.g. means to reduce hazards by using the inherent safety concept or Differential Scanning Calorimetry, DSC) and protection measures must be considered. If handling hazardous materials is considered too risky, procedures for generation of the hazardous reactants in situ in the reactor might be developed. Micro-reactor technology could also be an option. Completeness of the data on flammability, explosivity, (auto)ignition, static electricity, safe levels of exposure, environmental protection, transportation, etc. must be checked. Incompatibility of materials to be treated in a plant must be determined. 

The progress in micro-reactor technology provides the background for the development of compact fuel processors and peripheral components of fuel cell systems. 

Akay, G. Dogru, M. Calkan, B. Calkan, O.F. Flow induced phase inversion phenomenon in process intensification and micro-reactor technology. Process intensification in water-in-crude oil emulsion separation by simultaneous application of electric field and polymeric demulsifiers. In Microreact Technology and Process Intensification Wang, Y., Halladay, J., Eds. Oxford University Press Oxford, 2005 Chapter, 18. 

Styring, P., Towards liquid crystal synthesis using high throughput and micro reactor technologies. Mol. Cryst. Liq. Cryst., 411,2004,1059-1070. 

In this study, after a brief introduction to PI we provide the bases of a technique for the preparation of polymeric micro-porous materials, known as polyHIPE polymers (PHPs) which are now used extensively in PIM, and micro-reactor technology. These polymers are prepared through the high internal phase emulsion (HIPE) polymerization route. In order to control the pore size, the flow-induced phase inversion phenomenon is applied to the emulsification technique. The metalization of these polymers and formation of nano-structured micro-porous metals for intensified catalysis are also discussed. Finally, we illustrate the applications of these materials in chemical- and bioprocess intensifications and tissue engineering while examining the existence of several size-dependent phenomena. 

V. Skelton,6taI.,Thepreparationofaseriesof nitrostilbene ester compounds using micro reactor technology. Analyst 2001, 126, 7-10. 

E. R. Delsman, E. V. Rebrov, M. H. J. M. De Croon, et al. MiRTH-e micro reactor technology for hydrogen and electricity, in Proceedings of the Fifth International Conference on Microreaction Technology, Springer, Berlin, 2001, 268-274. 

Although the rapid growth of micro-reactor technology has led to the transfer of many common synthetic reactions from batch to chip little attention has been paid to the problems associated with the continuous purification of these reaction products. To tackle this, the incorporation of solid-supported catalysts within miniaturised flow reactors, leading to the synthesis of analytically pure compounds and aiding the development of efficient multi-step processes. 

Coming have, over many years, developed micro-structure technologies and are able to generate features in materials with mm to micrometer channel sizes. The target is principally to develop reactors based on this expertise to replace batch pharmaceutical plants with throughputs to lOkte/yr upwards with micro-reactor technology. Their system was launched at AChEMA in 2006. 

Process intensification and inorganic synthesis - including micro-reactor technology, membrane reactors sand catalyst coating. 

Mills PL, Quiram DJ, Ryley JF Micro reactor technology and process miniaturization for catalytic reactions—a perspective on recent developments and emerging technologies, Chem Eng Sci 62 6992-7010, 2007. http //dx.doi.Org/10.1016/j.ces.2007.09.021. 

Frost, C.G. and Mutton, L. Heterogeneous Catalytic Synthesis Using Micro-reactor Technology. Green Chemistry 12,1687—1703 (2010). 

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