Guinea worm

Guinea worms Guimer-Preston zones Guinier radius L-Gulose [6027-89-0]... 

Dracontiasis (guinea worm) Dracunculus medinensis Thiabendazole or Mebendazole... 

Metronidazole is the drug of choice in Europe for anaerobic bacterial infections concern about possible carcinogenicity has led to some caution in its use in the United States. Recently it has been found to be effective in treating D. medinensis (Guinea worm) infections and Helicobacter pylori... 

FA046 Joshi, P. Herbal drugs used in Guinea worm disease by the tribals of southern Rajasthan (India). Int J Pharmacog 1991 29(1) 33-38. FA059... 

Dracunculus medinensis (guinea worm) Metronidazole Thiabendazole or mebendazole... 

Guinea worm /rJcdiYJcnsJS metronidazole, mebendazole Rapid symptom relief... 

Niridazole is used in the treatment of schistosomiasis and of guinea-worm Dracunculus medinensis) infections it is given in divided daily doses of 25 mg/kg for 5-10 days, depending on the infecting species. Niridazole is well tolerated in Schistosoma hematobium infections. It is metabolized in the liver, and its metabolites color the urine dark brown. In the treatment of schistosomiasis it has been largely superseded by newer drugs. 

According to Ramadan and cowoikers (36), aqueous extract of the baobab fruit pulp produces a marked anti-inflammation activity. The effect was comparable to that induced by standard phenylbutazone (15 mg/kg). This antiinflammatory effect may be due to the presence of sterols, saponins and triterpenes in the aqueous extract. The extract also shows a marked antipyretic activity (36). The antipyretic activity of the extract resembles that normally induced by standard dose of administered acetylsalicyhc acid (ASA) in hyperthermic rats. Leaves are applied locally for a variety of inflammatoiy conditions, insect bites and guinea worm sores (8). Anti-pyretic activity has been reported (36). 

Africa leaves diaphoretic, expectorant, prophylactic against fever, excessive perspiration, astringent, treatment kidney and bladder diseases, asthma, general fatigue, diarrhoea, inflammations, insect bites, Guinea worm, hyposensitive, antihistamine properties, sources with poultices 3, 10)... 

The guinea worm infection is a very old parasitic disease caused by Dracuncu-lus medinensis which are enlongated thread-like filarial worms living in the deep connective and subcutaneous tissues of man. The infection has been reported from different parts of Africa, South America and Asia however, it is endemic in Cameroon, Lake Chad, Sudan, Uganda and India. 

Humans become infected with guinea worms by drinking water contaminated by infected Cyclops. On reaching the intestine, the Ci/clops get digested by gastric juice liberating free larvae which pierce the intestinal mucosa and reach the connective tissues where they live and attain sexual maturity in about a year. 

Guinea worm infection Dracunculus tnedinensis Thiabendazole, niridazole, metronidazole... 

Some 5-nitro-l,2-disubstituted-imidazoles of the type 11 and 12 have been shown to have appreciable in vitro and in vivo antischistosomal activities, but none find use in clinical practice [21]. However, metronidazole (13) has been used widely to treat guinea worm (Dracunculus medineusis) infection in human [22]. 

Metronidazole is a well tolerated drug causing expulsion or lysis of the guinea worms. However, the patient may experience nausea, vomiting, weakness, insomnia, headache, dry mouth and metallic taste. 

Guinea worm Dracuncelus medinensis Africa, India 79 ... 

It is the anthelmintic drug of first choice in hookworm, pinworm, roundworm, whipworm, guinea worm, in filariasis, and also as an alternative drug for Visceral Larva Migrans. It is also employed as an adjunct to steroids for curing trichinosis. 

It is also the drug of choice for the treatment of Dracunculus (guinea worm). 

Behrbohm P, Zschunke E (1965) Allergisches Ekzem durch das Antimykotikum Afungin (Dibenzthion). Dermatol Wochenschr 151 1447-1453 Belcher DW, Wurapa FK, Ward WB (1975) Failure of thiabendazole and metronidazole in the treatment and suppression of Guinea worm disease. Am J Trop Med Hyg 24 444-446... 

N early 60% of illness around the world is due to contaminated water and lack of sewer treatment. According to the World Health Organisation (WHO), about 2.4 billion people do not have access to basic sanitation facifities, and more than one billion people do not have access to safe drinking water. Unclean water causes diarrhoea, cholera, dysentery, guinea worm infection, typhoid, intestinal worm infection and trachoma [3]. According to the WHO, four bilfion people get diarrhoea every year that kills nearly 1.8 million people of which 90% are children under the age of five. 

Traditional use A water infusion of the aboveground parts is used to treat colitis, intestinal colic, and as a laxative for constipation, as well as a hemostatic to treat hemoptysis, and menstrual and hemorrhoid hemorrhages. A water extract of the dried plant collected during flowering stage is used as an antiprotist and antibacterial. A decoction of the roots is used to treat guinea worm and jaundice. Young stems are used as a source of vitamins. Leaves are used as a diuretic and a decoction of the leaves is used to treat headaches (Zolotnitskaya 1965 Makhlayuk 1967). 

Erysipelas po>Ka (6ojie3Hb) Guinea worm pHUIXa, rBHHeHCKHH HepBb... 

Guinea worm Worm (Dracunculus medinensis) Larvae are ingested when water flea host is swallowed. Worm grows for one year and then exits through skin lesion. 

Dracunculiasis Skin disease caused by a parasitic helminth, the guinea worm Dra-cunculus medinensis. 

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