4- methylbenzoyl chloride

Scholl and co-workers [91] performed the acylation of l-benzoylpyrene with 4-methylbenzoyl chloride in a NaCl/AlCl3 (X(A1C13) = 0.69) molten salt (110-120 °C). This gave l-ben2oyl-6-(4-methylben2oyl)-pyrene as the major product (Scheme 5.1-59). 

Beilstein Handbook Reference) Benzoyl chloride, 4-methyl- BRN 0471492 EINECS 212-864-8 4-Methylbenzoic acid chloride 4-Methylbenzoyl chloride p-Methylbenzoyl chloride p-Toluic acid chloride 4-Toluoyl chloride p-Toluoyl chloride p-Toluyl chloride. Used in chemical synthesis. Liquid mp = -1,5° bp 226° d = 1.1686 soluble in CCU. James River Sigma-Aldrich Fine Chem. 

Acylium salts are generated at slightly higher temperatures or with more reactive acyl halides. For example, both 4-methylbenzoyl chloride and 2,4,6-trimethylbenzoyl... 

Key precursors in the preparation of zoxamide are 3,5-dichloro-4-methylbenzoyl chloride (16) and 3-amino-3-methyl-l-pentyne (17). Compound 16 is prepared... 

CAS 874-60-2 EINECS/ELINCS 212-864-8 Synonyms 4-Methylbenzoyl chloride p-Methylbenzoyl chloride... 

Preparation of Ketones. l-[(Trimethylsilyl)methyl]benzo-triazole reacts readily with acyl chlorides to provide the corresponding (benzotriazol-l-yl)methyl ketones in good yields. One example of such reactions is given in eq 1, and similar results are reported for reactions with benzoyl, acetyl, phenylacetyl, and other acyl chlorides. As shown by an example in eq 2, the benzo-triazolyl moiety in (benzotriazol-l-yl)methyl ketones is easily removed by reduction with zinc in acetic acid to provide the corresponding methyl ketones. To prepare higher ketones, lithi-ated l-[(trimethylsilyl)methyl]benzotriazole is alkylated first and then subjected to the regular reactions with acyl chlorides and zinc. Thus, in a reaction of l-[(trimethylsilyl)methyl]benzotriazole with -BuLi followed by benzyl bromide, l-[ l-(trimethylsilyl)-2-phenylethyljbenzotriazole is obtained in 81% yield. Subsequent treatment of this product with 4-methylbenzoyl chloride and then with zinc in acetic acid provides 4-methylphenyl 2-phenylethyl... 

A new synthesis of emodin has been reported 165) (Scheme 17). Thus the Friedel-Crafts acylation of methyl 3,5-dimethoxybenzoate with 2-methoxy-4-methylbenzoyl chloride followed by hydrolysis of the ester yielded the benzophenone (160). Cyclisation and demethylation was accomplished by treating (160) with an aluminium chloride-sodium chloride melt yielding emodin (161). 

Preparation by reaction of 2-methoxy-4-methylbenzoyl chloride with benzene in the presence of aluminium chloride in tetrachloroethane [6], according to [14]. Also refer to [76,226,608]. yellow oil [598] ... 

Obtained by Friedel-Crafts acylation of pyrogallol trimethyl ether with 3-methoxy-4-methylbenzoyl chloride in the presence of aluminium chloride in boiling carbon disulfide for 4 h (22%) [1169,1170]. 

Obtained by heating for 4 h a mixture of 2-chloroanisole and 4-methylbenzoyl chloride. 

Isolated as a co-product from the preparation of 2,3-di-methoxy-4-methylacetophenone, obtained by conversion of 2,3-dimethoxy-4-methylbenzoyl chloride with methyl cadmium (10%) [3022]. 

Obtained by reaction of methyl iodide with 2-methoxy-4-methylbenzoyl chloride in the presence of zinc in an ethyl acetate/toluene mixture (68%) [7309]. 

The effect of temperature, time, and amount of AICI3 on the acetylation of some alkyl-cyclohexyl-benzenes has been studied. The product mixtures from the benzoylation of toluene with 2-, 3-, and 4-methylbenzoyl chlorides in the presence of FeCls or AICI3 have been analysed. Analogous studies on the xylenes and mesitylene have been published, and 2-, 3-, and 4-chlorotoluenes have been chloroacetylated with CICH2COCI and AICI3 or FeCh. ... 

Methylbenzoyl chloride added dropwise at 0° to ethereal diazomethane, kept 20 hrs. at 0-5°, then evaporated in vacuo 4-methylhenzoyldiazomethane (Y 81%) and 3,5-dimethylpyrazole in ether irradiated 20 hrs. with a water-cooled immersion lamp -> N -(4-methylphenacetyl)-3,5-dimethylpyrazole (Y 90%) in abs. ether stirred and treated portionwise at 0° with LiAlH4, stirring continued 10 hrs. at 0°, then treated with 2 N H2SO4 4-methylphenylacetaldehyde (Y 76%). F. e., procedures, and methods s. W. Ried, G. Deuschel, and A. Kotelko,, 642, 121 (1961). 

---