M-Toluyl chloride

A determination of traces of low (Ci to C4) aliphatic amines in the atmosphere consists of passing air through an absorber containing phosphorous acid, derivatizing with m-toluyl chloride and end analysis by HPLC-UVD LOD 1-5 pmol of amine, corresponding to concentrations lower than 0.1 pg/m3 of air, in a 300 L sample232. 

Acylation of amines is often put to practical use. For example, the insect repellent OFF is the amide formed in the reaction of m-toluyl chloride and diethylamine. 

Dissaccharides. A mixture of 3,5-di-0-p-toluyl-2-deoxy-D-ribose, active Ag-carbonate according to M. L. Wolfrom, A. O. Pictet, and I. C. Gillam, Proc. Nat. Acad. Sci. U. S. A7, 700 (1961), some Ag-perchlorate, Drierite, and toluene shaken 5 min. in the dark, treated with a suspension of 3,5-di-0-p-toluyl-2-deoxy-D-ribofuranosyl chloride in toluene, and shaking continued 4 hrs. in the dark 3,5-di-0-p-toluyl-2-deoxy-D-ribofuranosyl 3,5-di-0-p-toluyl-2-deoxy-D-ribofuranoside. Y 41%. J. Pliml and F. Sorm, Coll. 32, 3060 (1967). 

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