1- methyl-2-trimethylsilyl

A closely related lithium amidinate with a pendant methyl(trimethylsilyl) amine functionality was prepared by the straightforward route outlined in Scheme 178 (55% yield)... 

The volatile components are chloroform, methanol, methyl iodide, methyl trimethylsilyl ether, and hexamethyldisiloxane. 

Adapted from Sasidharan and Kumar (257). Reaction conditions catalyst, 150 mg methyl trimethylsilyl dimethylketene acetal (silyl enol ether), 10 mmol a,(3-unsaturated carbonyl compounds, 10 mmol dry THF, 10 mmol reaction temperature, 333 K reaction time, 14 h. Structures of a, p-unsaturated carbonyl compounds (2a-2g) and products (3a-3g) are shown in Scheme 24. 

Few ketene acetals with electron-accepting substituents are known. Ainsworth et al. (43,44) have described a number of methyl trimethylsilyl acetals (25,... 

The mechanisms for nucleophilic GTP and electrophilic GTP are not the same. Electrophilic GTP proceeds by an associative or concerted mechanism that does not involve anionic propagating centers. Initiation involves a concerted addition of methyl trimethylsilyl dimethyl ketene acetal to monomer to form species XXV. The overall effect is to transfer... 

For groups experienced in trace analysis of chemical markers for bacteria, currently samples are analyzed almost exclusively by GC-MS/MS. GC-MS/MS assays are now well established and a wide range of clinical and environmental samples have been analyzed. However, application in the pharmaceutical industry requires further evaluation. For example, Mur is released by hydrolysis and analyzed as an alditol acetate 3-OH FAs after methanolysis are converted to methyl trimethylsilyl derivative. Detailed analytical procedures have been described elsewhere for Mur [3,4,7, 8,11] and for 3-OH FAs [2, 5,12,13]. The compounds of interest contain active... 

Introducing the Tau residue into a peptide according to the first approach demands protection of the amino group, usually in the form of a Z-derivative and turning the sulfonic acid into sulfonyl chloride. Synthesis of (j-su Ifonamidopeptides via an iterative process, both in solution and in the solid phase, has been described.11201 Chiral methylene sulfinamide peptides can be synthesized both in solution and in the solid phase using the sulfonyl chlorides derived from enantiomerically pure 2-substituted taurines under mild coupling conditions (DMAP catalysis and excess methyl trimethylsilyl dimethylketene acetal as a proton trap).11261... 

The analogous reaction, the alkylation of methyl (trimethylsilyl)methyl ether with alkyl iodide/AgBF4, and the reaction in Eq. (4.15) have been employed to prepare tertiary [(trimethylsilyl)methyl]oxonium salts. 

ENOL TRIMETHYLSILYL ETHERS Methylketene methyl trimethylsilyl acetal 2-Oxo-3-trimethylsilyltetrahydro-1,3-oxazole. 

Mcthy lene-y-butyrolactones, 136 0-Methylene cyclic ethers, 270 6-Methylene-3-ketoA -steroids, 193 3-Methyleneoxolanes, 136 Methylenetriphenylphosphorane, 338-339 Methyl enol ethers, 273-274, 401 Methylenomycin B, 14, 162 14a-Methylestrone 3-methyl ester, 95 0-Methylhomoallyl alcohols, 143 Methylidenation, 182 Methyl jasmonate, 279, 301 Methylketcne methyl trimethylsilyl ketal, 340 Methyl lithiodithioacetate, 340 Methyl 5-lithiotetronates, 72, 73 Methyllithium-Tetramethylethylcnediamine,... 

The methyl(trimethylsilyl)phosphines PMen(SiMe3)3 decrease in base strength as n decreases, until finally P(SiMe3)3 does not react at all (entries 28, 29). 

Methyl-(trimethylsilyl)methyhminoacetate, chosen as the azomethine ylid precursor, provides an elegant access to proline derivatives. However, the cycloaddition reaction has a low regiospecificity.386... 

Phosphorsdure-chlorid-methylester-(methyl-trimethylsilyl-amid) (88% Sdp. 55—60°/0,l Torr/13 Pa) ist auf folgende Weise zuganglich348 ... 

Uberschussiges Thiophosphorylchlorid reagiert mit Heptamethyldisilazan zu Thiophos-phorsaure-dichlorid-(methyl-trimethylsilyl-amid) (72% Sdp. 36—3870,03 Torr/4 Pa)47 ... 

Dichlorphosphoryl-(dichlor-thiophosphoryl)-mcthyl-amin entsteht auch durch Kochen von Thiophosphorsaure-dichlorid-(methyl-trimethylsilyl-amid) mit iiberschiissigem Phosphorylchlorid (Ausbeute 42%)47. Analog reagiert Thiophosphorsaure-difluorid-(methyl-trimethylstannyl-amid) mit Pyrophosphorylfluorid zu Difluorphosphoryl-(di-fluor-thiophosphoryl)-methyl-amin (88% Sdp 47°/20 Torr/2,7 kPa)50 ... 

Methyl Trimethylsilyl Tellurium1,5 2.3 g (15 mmol) of crude lithium methanetellurolate, prepared from methyl lithium and tellurium in tetrahydrofuran, are combined with 1.7 g (15.7 mmol) of chlorotrimethylsi-lane at 25°. The reaction is vigorous and exothermic. After 1 h, all volatile material is pumped from the reactor in through traps at — 45° and - 196°. The material in the - 45° trap is distilled through a series of traps at — 23°, — 45 , and — 196°. The pure product condenses in the — 45° trap yield 2.0 g (64%) vapor pressure 3 torr at 25". 

Methyl trimethylsilyl tellurium and phenyl trimethylsilyl tellurium exchanged the organyltelluro group for halogen in reactions with silyl, germyl, stannyl and plumbyl halides2. 

Excess methyl trimethylsilyl tellurium with dimethyl germyl dichloride produced dimeth-ylgermylene bis [methyl tellurium] in 89% yield. Use of equimolar amounts of the reactants formed mainly dimethyl(chloro)germyl methyl tellurium2. 

A similar reaction between 4-methyl trimethylsilyl tellurium and cadmium(TI) chloride in tetrahydrofuran at room temperature yielded bis[4-methylphenyltelluro] cadmiuml. 

Methyl trimethylsilyl tellurium and toluenesulfonylazo compounds reacted in acetonitrile in the presence of 18-crown-6 at 20° to give aryl methyl tellurium derivatives3. 

Methyl trimethylsilyl tellurium, generated from lithium methanetellurolate and trimethylsilyl chloride in tetrahydrofuran, reacted with 4-methylbenzenesulfonylazoarenes in acetonitrile at 20° to produce aryl methyl tellurium products in moderate yields2. 

Derivatization of non-volatile polar or thermally sensitive compounds to enhance their volatility and stability prior to chromatography is a well-established technique. Compounds containing hydroxyl, carboxyl and amino functional groups can be readily reacted with appropriate reagents to convert these polar groups into much less polar methyl, trimethylsilyl or trifliioroacetyl derivatives of greater volatility. Fatty acids. Carbohydrates. 

---