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Methylation, of sugars

Glucosylated oligonucleotides obtained from T4 phage DNA by acid DNase digestion are resistant to spleen exonuclease (28). It has been reported that acetylation of the 2 -OH groups of tRNA completely inhibits the action of the enzyme, whereas venom exonuclease is not affected (29). The naturally occurring methylation of sugars and bases in tRNA does not seem to hinder the action of spleen exonuclease. [Pg.333]

Methyl sulfate, methylation of sugars by, history of, 1 Methylation... [Pg.512]

This reaction has been used for the structural analysis of polysaccharide and the methylation of sugars. [Pg.1527]

Dimethyl sulphate is of particular value for the methylation of phenols and sugars. The phenol is dissolved in a slight excess of sodium hydroxide solution, the theoretical quantity of dimethyl sulphate is added, and the mixture is heated on a water bath and shaken or stirred mechanically (compare Section IV, 104). Under these conditions only one of the methyl groups is utilised the methyl hydrogen sulphate formed in the reaction reacts with the alkali present. -... [Pg.303]

Etherification. The reaction of alkyl haUdes with sugar polyols in the presence of aqueous alkaline reagents generally results in partial etherification. Thus, a tetraaHyl ether is formed on reaction of D-mannitol with aHyl bromide in the presence of 20% sodium hydroxide at 75°C (124). Treatment of this partial ether with metallic sodium to form an alcoholate, followed by reaction with additional aHyl bromide, leads to hexaaHyl D-mannitol (125). Complete methylation of D-mannitol occurs, however, by the action of dimethyl sulfate and sodium hydroxide (126). A mixture of tetra- and pentabutyloxymethyl ethers of D-mannitol results from the action of butyl chloromethyl ether (127). Completely substituted trimethylsilyl derivatives of polyols, distillable in vacuo, are prepared by interaction with trim ethyl chi oro s il an e in the presence of pyridine (128). Hexavinylmannitol is obtained from D-mannitol and acetylene at 25.31 MPa (250 atm) and 160°C (129). [Pg.51]

In recent year s, clinical studies on the role of uiinai y luodified nucleosides as the biochemical mai kers of various types of cancer have been actively undertaken. Most of the urinai y modified nucleosides ai e piimai ily originated by methylation of either the base part, the sugar hydroxyl par t, or in some cases, both par ts of the course of biodegradation of tRNA molecules. Hence, their isolation and identification plays a major role in biochemical analysis. [Pg.351]

The synthesis of halodeoxy sugars has also been achieved by reaction of sugar phosphorodiamido and phosphonamido derivatives with alkyl halides (83). Heating equimolar amounts of 6-(tetraethylphosphoro-diamido)-l,2 3,4-di-0 isopropylidene-D-galactose with methyl iodide (and benzyl bromide) at 140°C. for 4 hours afforded the 6-deoxy-6-iodo (74b) (75%) and 6-bromo-6-deoxy (74c) (56%) derivatives, respectively. [Pg.186]

The positions, numbers, and types of sugars on the anthocyanin molecule influence its bioaccessibility. Indeed, a recent human study reported that the acylation of anthocyaifins resulted in a sigififlcant decrease of anthocyanin recoveries in plasma and urine. In addition, anthocyanins form linkages with aromatic acids, aliphatic acids, and methyl ester derivatives, which can also affect their passage through the intestinal barrier. [Pg.158]


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See also in sourсe #XX -- [ Pg.166 ]

See also in sourсe #XX -- [ Pg.4 , Pg.7 , Pg.10 , Pg.11 , Pg.12 , Pg.13 , Pg.14 , Pg.15 , Pg.16 , Pg.17 , Pg.24 , Pg.30 ]

See also in sourсe #XX -- [ Pg.4 , Pg.10 , Pg.11 , Pg.12 , Pg.13 , Pg.14 , Pg.15 , Pg.16 , Pg.17 ]

See also in sourсe #XX -- [ Pg.9 ]




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Demethylation, of methylated sugars

Glycosides methyl, of the common sugars

Jeanloz, Roger W., The Methyl Ethers of 2-Amino-2-deoxy Sugars

Methyl ethers of 2-amino-2-deoxy sugars

Of methylated sugars

Of methylated sugars

Of partially methylated sugars

Permethylated Sample, and Analysis of the Partially Methylated Sugars

Separation of methylated sugars

Sugar methylation

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