Methyl 3-tolyl ketone

Many aldehydes and ketones can be reduced directly by Clenimemen s method, in which the aldehyde or ketone is boiled with dilute hydrochloric acid and amalgamated zinc. />-Methylacetophenone (or methyl />-tolyl ketone) is reduced under these conditions to />-ethyltoluene. An excess of the reducing agent is employed in order to pre ent the formation of unsaturated hydrocarbons. 

The crude product consists of />-toluic acid contaminated with small amounts of terephthalic acid, methyl -tolyl ketone, and nitration products. 

About 300 ml. of distillate is collected, of which 5 ml. consists of methyl -tolyl ketone. 

Other phosphonmm salts which may be obtained from the chloride in the usual manner are as follows, the compounds in brackets being the decomposition products formed when the salts are heated to a high temperature bromide (almost totally decomposed only resembles the chloride to a slight extent) hydroxide (triethylphosphine oxide, toluene), carbonate and acid carbonate (triethylphosphine oxide, toluene, carbon dioxide) sulphate (2 mols. trietfylphosphine oxide, stilbene, carbon dioxide) acetate (triethylphosphine oxide and methyl tolyl ketone, and to a smaller extent triethylphosphine and the methyl ester of toluic acid) oxalate (triethylphosphine oxide, toluene, carbon monoxide, carbon dioxide). 

See Methyl tolyl Ketone. Methyl< -acetopropylcarbinol. See 2-Heptanolone-6. 4-Methyl..3-acetopyrazole... 

We have also examined the behavior of copolymers of o-tolyl vinyl ketone and methyl vinyl ketone (CoMT). In this case the light is absorbed exclusively at the aromatic carbonyl chromophore and the reaction proceeds from this site, while the methyl vinyl ketone moieties provide a relatively constant environment but prevent energy migration along the chain. The values of Tg and Tip in benzene have been included in Table II. These copolymers axe also soluble in some polar solvents for example, we have used a mixture of acetonitrile acetone methanol (30 30 Uo, referred to as AAM). This mixture is also a good solvent for the electron acceptor paraquat (PQ++) which has been shown to be good biradical trap in a number of other systems (9.). 

Stereochemistry of this reaction is also quite interesting. Thus, both geometrical isomers of 1-chlorovinyl p-tolyl sulfoxides (165-167) were synthesized from 2-cyclohexenone, methyl vinyl ketone and 2-heptanone respectively, and the corresponding magnesium alkylidene carbenoids were generated and treated with A-lithio aniline or A-lithio 1-aminonaphthalene. The results are summarized in Table 9. 

Methyl o-tolyl ketone. (6) wo-Propyl phenyl ketone. (11) w-Hydroxyacetophenone. 

A mixture of 3-methyl-97/-fluoren-9-one (79) [prepared from 2-aminophenyl-4-tolyl ketone (78) f217 2201 5.82g, 30mmol)],NBS (5.34g, 30mmol), and (BzO)2 (0.5 mg, 2.1 mmol) in CC14 (50mL) was stirred at rt for 2h, then refluxed for 2h. The hot soln was filtered and washed with hot CC14 until the solid became almost colorless. The yellow crystals (6.71 g) obtained from the concentrated filtrate (80 mL) were filtered and washed with cold CCl4(5mL). This crude product 80 contained 79 (ca. 5%) and the dibromo... 

Toluene reacted with III and aluminum chloride much as did benzene, except that yields were lower and tar formation more extensive. From the organic layer methyl p-tolyl ketone was isolated, while acetylation of the product from the aqueous layer led to 1,1-di-p-tolyl- 1-desoxy-D-glucitol hydrate (VI). p-/3-D-Glucopyranosyltoluene, structurally... 

SYNS p-ACETYLTOLUENE ETHANONE, l-(4-METHYLPHENYL)-(9CI) FEMA No. 2677 MELILOTAL p-METHYL ACETOPHENONE 1-METHYD4-ACETYLBENZENE METHYL-p-TOLYL KETONE... 

SYNS p-BENZOPHENONE, METHYL- PHENYL p-TOLYL KETONE USAF DO-54... 

Isomerism of Ketoximes.—In the case of aromatic aldehydes they all yield these stereo-isomeric oximes. With the aromatic ketones the condition is different and some yield stereo-isomers and some do not. With symmetrical aromatic ketones in which the two radicals are alike such as di-phenyl ketone, CgHb—CO—C6H,5 no different space relation of the hydroxyl group is possible as the two forms will be identical. When, however, the ketone is unsymmetrical, i.e.j the two radicals are unlike, as in mixed aromatic-aliphatic ketones such as phenyl methyl ketone, CeHs—CO—CH3, or in unsymmetrical di-aryl ketones such as phenyl tolyl ketone, CeHs—CO—C6H4—CHz then the two stereo forms are possible though both forms are not known in all cases. 

The same reaction with methyl p-tolyl ketone gave a ) -hydroxycyclopropyl selenide which upon treatment with p-toluenesulphonic acid underwent ring expansion to 2-methyl-2-p-tolylcyclobutanone, a precursor of a-cuparenone. ... 

BTA = benzoyl-N-(o-tolyl)hydroxyl amine CPCHA = chiorophenylcinnamohydroxamic acid GFAAS = graphite furnace atomic absorption spectrometry ICP-AES = inductively coupled plasma atomic emission spectrometry IDMS = isotope mass spectrometry MIBK = methyl isobutyl ketone NAA = neutron activation analysis... 

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