2-methyl-5-phenyl-4- oxazole

Bis-[ ( benzo-1,3-oxazol) -yl-(2)-thio]- 343 Bis-[1,4- (bzw. 3,4]-dihydro-naphthy[-(2)-oxy]- 588 Bis-[dimethylamino]- 345 Bis-[4-dimethyIamino-phenyl]- 346 Bis-[4-hydroxy-phenyl]-(2-carboxy-phenyl)- 167 Bis-[4-methoxy-phenyl]-dideutero- 346 Bis-[4-methyl-phenyl]-Bis-f 2-methyl-thiiranyl-(2)]- 570 Bis-[naphthyl-(2)-oxy]- 588 Bis-[naphthyl-(2)-thio]-... 

The pH of the reaction stream was adjusted to neutral and the dark stream was washed with methyl-t-butyl ether to remove neutral organic impurities. The major impurity observed in the MTBE wash is phenyl oxazole formed by de-iodination of the starting iodoxazole. Phase separation of this wash is a difficult one due to the dark color of the reaction stream. 

Methyl-2-phenyl-oxazol-4-yl)ethoxy]benzo[2]thiophen-7-yl]methyl]-thiazolidine-2,4-dione. 

Br —CHj ch3 c6h. (nh2-oh) [4-(2-Brom-4-methyl-phenyl-azo) -3-methyl-5-phenyl-1,2-oxazol 90 105 1... 

Methyl-2-phenyl-oxazole derivatives, (VI), (VII), and (VIII), prepared by Kuwabara (7), Fakhoury (8), and Tajima (9), respectively, were effective in the treatment of hyperlipidemia associated with Type II diabetes. 

Preparation of 5-(3-(2-(5-methyl-2-phenyl-oxazol-4-yl)ethoxy)benzyl)-2-phenyl-4-A-phenylamido-l, 2,3-triazole... 

Oxalactims, for exanple 5//-methyl-2-phenyl-oxazol-4-one, were investigated as synthetically powerful synthons for the construction of a-hydroxy acids via o -deprotonation followed by molybdenum-catalyzed asymmetric allylation and a subsequent hydrolysis of the oxalactim rings. Among the series of the HMDS bases used in tbe Mo-catalyzed asymmetric allylation, LHMDS was found to be tbe base of choice providing better yields, regio- (branched/Unear), diastereo- andenantioselectivity than the corresponding allylation reactions mediated by KHMDS (eq 63). ... 

Methyl-5-phenyl-oxazol 27 1217. 5-Methyl-2-phenyl-oxazol 27 I 218. Verbinduag C,oH30 aua l-Methyl-8-oxy-... 

The reverse reactions of Diels-Alder reactions for thermal dissociations of cycloadducts in to dienes and dienophiles at higher temperatures or in the presence of Lewis acid or base are known as the retro-Diels-Alder (rDA) reactions. These reactions in most cases proceed in a concerted process. These reactions are often used for separation of diene or dienophile from their mixture with other compounds. Proper selection of conditions of these reactions provides new dienes and dienophiles, which are important synthons for synthesis of several bioactive natural products and organic molecules of complex structures. For example, the D-A adduct of 4-phenyl oxazole 110 with methyl acetylene dicarboxylate, on retro-D-A reaction gives new compounds, benzonitrile, and furan 3,4-dicarboxylic acid methyl ester 111 [65]. 

Oxazoles.—Recent developments in the chemistry of oxazolinones have been reviewed. Tosylalkyl isocyanides TosCHRNC (R = alkyl) react with aromatic aldehydes to form oxazoles (546). The action of hydrogen chloride on a mixture of benzoyl cyanide and an aromatic aldehyde results in chloro-oxazoles (547). Tungsten(vi) chloride catalyses the formation of 2-methyl-5-phenyl-oxazole (548) from acetonitrile and diazoacetophenone/ Thermolysis of the... 

Methyl groups on C-linked phenyl attached to oxazoles, isoxazoles and oxadiazoles react with benzylidineaniline to give stilbene derivatives (Scheme 51) <78AHC(23)l7l). 

Oxazol-4(5ff)-one, 5-acetyl-5-methyl-synthesis, 6, 225 Oxazol-4(5ff)-one, 2-phenyl-photorearrangement, 6, 200 synthesis, 6, 225 Oxazol-5(2ff)-one, 2-acyl-2,4-disubstituted pyrolysis, 6, 200 Oxazol-5(2H)-one, allyl-photochemical rearrangement, 6, 200 Oxazol-5(2ff)-one, 2-arylmethylene-synthesis, 6, 227... 

Oxazol-5(2H)-one, 2-benzylidene-4-methyl-tautomerism, 6, 186 Oxazol-5(2ff)-one, 2-methylene-isomerization, 6, 226 Oxazol-5(2H)-one, 2-trifluoromethyl-acylation, 6, 201 Oxazol-5(4ff)-one, 4-allyl-thermal rearrangements, 6, 199 Oxazol-5(4H)-one, 4(arylmethylene)-Friedel-Crafts reactions, 6, 205 geometrical isomerism, 6, 185 Oxazol-5(4ff)-one, 4-benzylidene-2-phenyl-configuration, 6, 185 photorearrangement, 6, 201 Oxazol-5(4ff)-one, 4-benzyl-2-methyl-Friedel-Crafts reactions, 6, 205 Oxazol-5(4ff)-one, 4-methylene-in amino acid synthesis, 6, 203 Oxazol-5(4ff) -one. 2-trifluoromethyl-hydrolysis, 6, 206 Oxazolones... 

Methyl-2-phenyl-4-athoxycarbonyl-l,5-dihydro-l,3-oxazol wird je nach Menge Li-thiumalanat entweder selektiv zum Alkohol reduziert oder man erhalt unter Ringspaltung 2-Benzylamino-3-hydroxy-butandiol-(1,3) (s. S. 347). 

Analog erhalt man aus 5-Oxo-2-phenyl-4,5-dihydro-1,3-oxazol 2-Benzoylamino-athanol5 (88% d.Th.) und mit Lithiumalanat aus 5-Oxo-4-methyl-2-benzyliden-2,5-dihydro-1,3-oxazol 2-Phenylacetylamino-propanol (30% d.Th.)6. Calciumboranat reduziert 5-Oxo-2-phenyl-4-benzyliden-4,5-dihydro-1,3-oxazol zu oc-Benzoylamino-zimtal-kohol1. 

Cyclische 0,N-Acetale vom Typ der 1,3-Oxazolidine und 2,5-Dihydro-l,3-oxazole werden durch Lithiumalanat7 und Natriumboranat8,9 zu 2-Amino-alkoholen reduziert. Aus 3-Methyl-2-phenyl-l,3-oxazolidin wird z.B. mit Natriumboranat 2-(N-Methyl-N-benzyl-amino)-athanol (74% d.Th) erhalten8 ... 

In the preparation of (2R,33, 7a3 )-2-phenyl-3-methyl-5-oxo-2,3,5,6,7,7a-hexahydropyrrolo-[2,T ]-oxazole 248, the reaction time is the most important parameter in the /ra r-halometallation. For instance, by stirring 246 with 1 or 2equiv of fer7-butyllithium in EtzO at — 78 °C for 30 min, 247 and the bicyclic lactam 248 were obtained as an equimolar mixture. The latter substance was isolated as a single product when the reaction time was increased to 120min for the reactions of 2-(2 -bromoethyl)oxazolidine 246 with fert-butyllithium (Scheme 36) <1996T10761>. 

The condensation of furo[3,2- ]pyrrole-type aldehydes 8g and 265-267 with hippuric acid was carried out in dry acetic anhydride catalyzed by potassium acetate as is shown in Scheme 26. The product methyl and ethyl 2-[( )-(5-oxo-2-phenyl-l,3-oxazol-5(4//)-ylidene)methyl]furo[3,2- ]pyrrol-5-carboxylates 268a-d were obtained. The course of the reaction was compared with the reaction of 5-arylated furan-2-carbaldehydes with hippuric acid. It was found that the carbonyl group attached at G-2 of the fused system 8 is less reactive than the carbonyl group in 5-arylated furan-2-carbaldehydes in this reaction <2004MOL11>. The configuration of the carbon-carbon double bond was determined using two-dimensional (2-D) NMR spectroscopic measurements and confirmed the (E) configuration of the products. 

Dimethyl-3-(2-oxo-2-phenyl-ethyl--bromid lagert sich beim Kochen mit Triethylamin in Acetonitril in 2-(2-Imino-5-phenyl-2,3-dihydro-oxazol-3-yl)-4,6-dimethyl-pyrimidin um. Aus diesem werden durch Kochen in Alkoholen mit 4-Methyl-benzolsulfonsaure als Katalysator 2-Alkoxy-l-(4,6-dimethyl-2-pyrimidyl)-4-phenyl-imidazole oder durch Erhitzen mit primaren oder sekundaren Aminen ebenfalls in Gegenwart von 4-Methyl-benzolsulfonsaure 2-Alkylamino-l-(4,6-dimcthyl-2-pyrimidyl)-4-phe-nyl-imidazole erhalten374 ... 

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