4- Methyl-3-phenyl- -Hydrochlorid

Bicyclo 4.2.0 octan 8-Cyan-1-pyrrolidino- IV/4, 285 Cyclobutan l,l-Dimethyl-2-di-methylamino-3-(4-pyridyl)- E17e, 143 ([2 + 2]-Cycloadd.) Cyclohexan 2-Hydrazino-l-(4-methyl-phenyl)- -Hydrochlorid E16a, 450/452 (Hydrazon-Red.)... 

Condensation of thiosemicarbazides of nicotinic and isonicotinic acids (528) and their hydrochlorides, with a-halocarbonyl compounds gave the corresponding hydrazinylthiazoles (149), in which Rj = methyl, phenyl, or aryl and R2 = H (Scheme 74). 

The discovery of oxazoline hydroxamates as potential inhibitors of LpxC was the result of high-throughput screening of large libraries of compounds at the Merck Research Laboratories in collaboration with the Department of Biochemistry, Duke University Medical Center [95]. The lead compound, L-573,655, was a racemic mixture of 4-carbohydroxamido-2-phenyl-2-oxazoline, which had been previously made by Stammer et al. [96] as a precursor in the chemical synthesis of cyclosporine. Namely, (R,S)-serine methyl ester hydrochloride (149) is converted into (R,S)-4-carbomethoxy-2-phenyl-2-oxazoline (150) via treatment with ethyl benzimidate using the Elliot procedure [97]. Treatment of this ester with one equivalent each of hydroxylamine and sodium methoxide in methanol at room temperature affords the desired (R,S)-4-carbohydroxamido-2-phenyl-2-oxazoline (151), as depicted in Scheme 30. 

R H5C6 N COOH H R - CH2-Cl 1. 6NHa Ruckfl. 18hB 2. Eindampfen (-+ HCI-Salz) 3. H20 RuckH. 12 h 2-(4-Hydroxy-methyl-phenyl) -dl -glycin-Hydrochlorid 82 171-173 (Zers.) 1... 

Nitro-2-hydrazinotoluene, It golden-yel or orn-yel ndls with a violet tinge (from ale), mp 179-80° diffc sol in hot ale xylene was prepd by heating the K salt of N-[4-Nitro-2-methyl-phenyl] -hydrazine-N,N -disul-fonic acid with coned HC1 (Refs 1 3) 3-Nitro-4-hydmzinotoluene, dk-red ndls (from eth), mp 110—11° v sol in acet sol in eth, chlf benz si sol in petr eth was prepd by diazotizing 2-nitro-4-methylaniline with Zn chloride HC1. Its Hydrochloride salt, C7H9N3O2+HCI, orn-red ndls or plates (from w) dec at 190-91° (Refs 2 4)... 

Diethyl l-[Amino(phenyl)methyl]phosphonate Hydrochloride Salt (2-HCI, R = H R2=Ph R3=Et) Typical Procedure 1221... 

BENZOFURANOL, 3-CHLORO-4- ((DIMETHYLAMINO)METHYL-2-PHENYL-. HYDROCHLORIDE... 

BENZOFURANOL, 4-( (DIMETHYLAMINO)METHYL)-2-PHENYL-, HYDROCHLORIDE 5-BENZOFURANOL. 4-( (DIMETHYLAMINO)METHYL)-3-PHENYL-, HYDROCHLORIDE 5-BENZOFURANOL, 4-BROMO-6-(DIMETHYLAMINOMETHYL)-2-PHENYL-5-BENZOFURANOL, 2-CHLORO-4- (DIMETHYLAMINOMETHYL)-3-PHENYL-... 

Chemical Name Acetamide, N-methyl-N-(4-((7-methyl-lH-imidazo[4,5-f]quinolin-9-yl)amino)phenyl)-, hydrochloride... 

Chemical Name a-Phenyl-2-piperidineacetic acid methyl ester hydrochloride Common Name -Structural Formula ... 

Amino-1 -methyl-ethan- -dialkylester XII/1,518f. 1-Amino-l-methyl-ethan- -diethylester XII/1, 485 Amino-(4-methyl-phenyl)-methan-Hydrochlorid XII/1, 356 l-Amino-2-mcthyl-propan- E2, 313... 

In 1981, Hirao and others reported that the chiral borane-amine complex 25a, derived from (S)-prolinol and 1 equivalent of BH3 THF, enantioselec-tively reduced propiophenone to afford (R )-l -phenyl-1 -propanol (26) in 44% ee9 (Scheme 4.3h). The chiral complex 25b was even better than 25a, affording the same secondary alcohol in 60% ee. Two years after the initial disclosure, Hirao et al. uncovered a new catalyst system that improved the previous experimental conditions dramatically10 (Scheme 4.3i). When the chiral aminoalcohol 27, prepared from (S)-valine methyl ester hydrochloride and phenylmagnesium bromide, was used along with 2 equivalents of BH3 THF, the enantioselectivity of the alcohol 26 jumped to 94% ee. In addition, the reaction time was shortened to 2 hours. 

Amino-1 -(4-methyl-phenyl)-1 -oxo-(Hydrochlorid) VII/2c, 2277 1 -Ethenyl-2-(2-pyridyl)- Vl/ld, 147f. 2-Methylamino-l-oxo-l-phenyl-(Hydrochlorid) Vll/2a, 348 Formamid N-(l-Phenyl-ethyl)- E16d, 734 (OH - NH-CHO) Clykolsaure Phenyl- -methylamid E5, 1004 (NH2 -> NH-CH3)... 

COOR + H2N-OH] 5-(Aminoxy-methyl)-3-phenyl- -Hydrochlorid E16a, 230 (O-Alkyl./N-Acylier.)... 

Amino-3-benzylthio- XV/I, 736 2-Amino-3-mercapto- -benzylester (Hydrochlorid) XI/2, 357 Sulfoximid S-(2-Acetyl-4-methyl-phenyl)-S-methyl- Ell, 1303 (RjSO + HN3)... 

Raney nickel) of the potassium salt of D-xy/o-5-hexulosonic acid oxime produces a mixture of 5-amino-5-deoxy-L-idonic and -D-glu-conic acid in the ratio of 2 1, which is converted into the methyl ester hydrochloride. Upon treatment with alkali, spontaneous cyclization to the pair of 1,5-lactams occurs. 5-Amino-5-deoxy-L-idono-l,5-lactam and 5-amino-5-deoxy-D-glucono-l,5-lactam were separated by recrystallization. The optical rotatory dispersion curves of both compounds were discussed. A new type of lactam, namely, 2-enamino-N,N -bis[(p-methoxycarbonyl)phenyl]-4-(D-gaiacfo-penta-acetoxypentyl)-4-butanelactam was prepared by tbe reaction of 5,6,7,8,9-penta-0-acetyl-3,4-dideoxy-D-ga/ocfo-nonulos- rcns-3-en-l-onic acid with methyl p-aminobenzoate. 

Propoxyphene Hydrochloride, Aspirin and Caffeine capsules (for Propoxyphene and Caffeine 0.6 M X 3 mm I.D. 3% Methyl Phenyl Silicone liquid/80-10 mesh siliceous earth Nitrogen 175 FID n-Tricosane USP (24, p. 1423)... 

Gougat, J., Ferrari, B., Sarran, L., Planchenault, C., Poncelet, M., Maruani, J., Alonso, R., Cudennec, A., Tiziano Crod, T, Fabio Guagnini, F., Katalin Urban-Szabo, K., Martinolle, J. R, Soubrie, R, Finance, O., Le Fur, G. SSR240612 [(2R)-2-[((3R>3-(l,3-Benzodioxol-5-yl)-3- [(6-methoxy-2-naphthyl)sulfonyl]amino propanoyl)amino] -3-(4- [2/J,6S)-2,6-dimethylpiperidinyl]methyl phenyl)-/V-isopropyl-/V-methylpropanamide Hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor biochemical and pharmacological characterization. J. Pharmacol. Exp. Then 2004, 309, 661-669. 

Mepben(ermine. N,a,a-Trimethylbenzeneethan-omine N, , trimethylphtnelhylamine 2-methylamino-2--methyl-1 -phenylpropane JV-methyl- -phenyl-lert-butyl. amine Wyamine Vial in Mephine. C H, N mol wt 163,25. C 8092%, H 10.50%. N 8,58%. Prepd by hydrogenating 1 -chloro-2 -methylamino-2-methyl- ]. phenyipropane hydrochloride in methanol in the presence of palladium barium carbonate Bruce, Szabo, U,S, pat. 2,597,445 (1952 to Wyeth). Alternate process Abel et at, US. pat. 2,890,079 (1952 to Wyeth). 

Ethyl (2E)-3-(dimethylamino)-2-(5-ethoxy-l-phenyl-lH-pyrazol-3-yl) propenoate (36) was prepared in two steps from ethyl (5-oxo-l-phenyl-4,5-dihydro-lH-pyrazol-3-yl)acetate (12) by treatment with ethyl bromide in ethanol under reflux to give ethyl (5-ethoxy-l-phenyl-lH-phenyl-3-yl) acetate (35), followed by treatment with DMFDM A in toluene under reflux. Compound 36 reacted with anilines, methyl glycinate hydrochloride, 3-amino-lf-f-indazole and 3-amino-5-methylisoxazol in ethanol in the... 

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