Methyl hydroxy propionate

Synonyms methyl hydroxy propionate Purasolv ML. Appearance methyl lactate occurs as a clear, colorless liquid. Boiling point 143.9°C... 

Cobalt tetracarbonyl anion in such hydroxylic solvents as water or methanol also reacts with epoxides at temperatures of 60—100 and at an elevated pressure of carbon monoxide (2000 Ib./in. ) to give esters of j8-hydroxy acids. Thus, ethylene oxide has been found to react with sodium cobalt tetracarbonyl and carbon monoxide in methanol solution at 65 and 2000 Ib./in. to give methyl 3-hydroxy-propionate in a yield of 55% the remainder of the product was acetaldehyde and an involatile oil. It was also shown that this reaction proceeds almost as well at a much lower pressure (three or four atmospheres of carbon monoxide). ... 

Protonated methyl l-amino-2-hydroxy-propionate SerCi C4H10NO2 120.13... 

Stanley, B. G., L. H. Ha, L. C. Spears and M. G. Dee, 2nd (1993). Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res 613(1) 88-95. 

CIC Methyl hexanoate represents the fresh, fruity character, ethyl-3-(methyl-thio)propionate imparts an overripe impression, l-(E,Z)-3,5-undecatrien adds a fresh green, biting topnote and 2,5-dimethyl-4-hydroxy-furan-3(2H)-one is responsible for the ripe, sugary, fruity, caramelic lasting aftertaste. Allyl hexanoate is often used in compounded pineapple flavourings. 

To allow for a diverse multi-step synthesis, we transformed the 3-hydroxy-2-methyl-idene propionic acids (Fig. 6.9) into polymer-bound allylic amines, which can be considered as unusual (3-amino acid derivatives. The polymer-bound allylic alcohols were first treated with acetyl chloride and DIEA in CH2C12 to form the ester, which was reacted with primary amines in an addition elimination step to form allylic amines. 

This variation was used for an enantioselectivc synthesis of antt O-methyl- hydroxy esters using the silylkctcttc acetal derived from (IK, 2 ) N methylcpbed rine 0-propionate (equation II). ... 

The backstory of this "just-puhlished paper on lactic acid" (CsHgOa) is important. We have already encountered lactic acid in the third section of chapter 4. Its constitution—formulable according to the dictates of the Kekul -Couper theory as either methyl glycolic acid or, what is the same thing, hydroxy propionic acid—was understood by... 

A side product, 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (HMBPA), can accumulate to high concentrations in the cultivation broth of (7 )-pantothenate-overproducing strains [177]. HMPBA formation is caused by premature a-KIV reduction to 2-hydroxyisovalerate (a-HIV) most probably by PanE before the molecule is hydroxymethylated (Figure 7.6). PanC-catalyzed condensation of a-HIV and P-alanine delivers HMBPA. 

CAS 547-64-8 EINECS/ELINCS 208-930-0 Synonyms Lactic acid methyl ester Methyl-S-(-)-2-hydroxy propionate Methyl DL-lactate... 

C4H8O3 2-hydroxy-propionic acid methyl ester 547-64-8... 

Irganox 245 Ciba-Geigy, Switzerland Triethylenglycol-bis-3-(3-tert-butyl-4-hydroxy-5-methyl phenyl propionate)... 

Fig. 10.4 Chromatogram of organic acids extracted from the same urine of the patient illustrated in Fig. 10.3, separated as their O-n-butyloxime and trimethylsilyl derivatives under the conditions described in the legend to Fig. 10.2. Peak identifications are 1, lactate 2, glycollate 3, unidentified 4, 2-hydroxy-n-butyrate plus 3-hydroxy-propionate 5, sulphate 6, 3-hydroxybutyrate and 3-hydroxyisobutyrate 7, 2-hydroxyisovalerate 8, 3-hydroxyisovalerate 10, 2-hydroxyisocaproate 11,2-hydroxy-3-methyl-n-valerate 12, phosphate 13,2-oxoisovalerate (peak 1) 14,2-oxoisovalerate (peak 2) 15, 2-oxo-3-methyl-/i-valerate (peak 1) 16, 2-oxo-3-methyl-n-valerate (peak 2) 17, 2-oxoisocaproate 18, citrate 19, 4-hydroxyphenyl-lactate 20, n-tetracosane (standard) 21, n-hexacosane (standard). The separation of O-n-butyloxime-TMS derivatives of the keto acids from the TMS-hydroxy acids and other components is apparent (compare with Fig. 10.3). Note the apparent loss of 4-hydroxyphenylpyruvate. (The horizontal axis represents the time elapsed in minutes from sample injection.)...

Chloro-9-fluoro-llb-hydroxy-16b-methyl-17-(l-oxopropoxy)-pregna-l,4-diene-3,20-dione. See Clobetasol propionate. 

A mixture of 50 grams of a-dl-1,2-diphenyl-2-hydroxy-3-methyl-4-dimethylaminobutane hydrochloride, 50 grams of propionic anhydride and 50 cc of pyridine was refluxed for about 5 hours. The reaction mixture was cooled to 50°C and ethyl ether was added to the point of incipient precipitation. The hydrochloride salt of 0 -dl-l,2-diphenyl-2-propion-oxy-3-methyl-4-dimethylamlnobutane formed in the reaction precipitated upon cooling and was removed by filtration and washed with anhydrous ether. On recrystallization from a mixture of methanol and ethyl acetate, a-dl-l, 2-diphenyl-2-propionoxy-3-methyl-4-dimethyl amlnobutane hydrochloride melted at 170°-171°C. 

C24H3,F20v5 80474-45-9) see Fluticasone propionate (6a, 11 p, 16ot, 17a)-6,9-difluoro-l 1-hydroxy- 16-methyl-3-oxo-17-(l-oxopropoxy)andro5ta-l 4-diene-17-carboxylic acid... 

Nofe. AMPA = amino-3-hydroxy-5--methyl-4-isoxazole propionate GABA=y-aminobutyric acid. 

Some derivatives of adamantane with antagonist or agonist effects have also been synthesized. For instance, monocationic and dicationic adamantane derivatives block the a-amino-3-hydroxy-5-methylisoxazole -propionic acid (AMPA) receptors, A-methyl-o-aspartate (NMDA) receptors [134—136] and 5-hydroxytryptamine (5-HT3) receptors [137]. 

AMPAR. (a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system. 

Non-NMDA ionotropic glutamate receptors (the majority sodium channel containing) can be subdivided into a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) (comprising cloned subunits GluRl ) and kainate (GluR5-7, KAl-2) preferring receptors, with native receptors most likely to comprise either homo- or heteromeric pentamers of these subunits. 

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