Methyl ester of formic acid

Van Alsenoy, C., J. N. Scarsdale, and L. Schafer. 1982. Ab Initio Studies of Structural Features Not Easily Amenable to Experiment Part 24. Molecular structures and conformational analyses of the methyl esters of formic acid, acetic acid and alanine. J. Mol. Struct. (Theochem) 90, 297-304. 

K-Stoff is a mixture of the incompletely chlorinated methyl esters of formic acid (70 per cent ClCOOCH Cl and 30 per cent ClCOt )-CHClj) and is a clear liquid, of 1.48. specific gravity, which boils at 1.09 C. (228.2 F.), yielding a vapor 4.5 times heavier than air. It has an ethereal odor, is somewhat lacrimatory, and hydrolyzes easily when warm and even when cold in the presence of alkalies, yielding formaldehyde, oarlmnic acid, and hydrochloric acid. Its vapor pressure at 20 C. (68 F.) is 5.6 mm. Hg. 

Trichlormethylchlorofonnate is the completely chlorinated methyl ester of formic acid and obtained by completing the chlorination of the monochlormethylehloroformate (K-Stoff). In. stmlying the chlorinated methyl c formic acid, the Gherman chemists found that their toxic propirrties increased, while their lacrimatory powers decreased, with... 

SYNONYMS formic acid methyl ester, methanoic acid methyl ester, methyl ester of formic acid, methyl methanoate. 

Synonyms/Trade Names Methyl ester of formic acid, Methyl methanoate ... 

In considering the influence of the number of halogen atoms present it is found that while one halogen atom confers predominantly lachrymatory properties on the molecule, an increase in the number of the halogen atoms diminishes the lachr5miatory but increases the asphyxiant action. A typical example of this observation is the series of halogenated esters of formic acid. In this the first member, monochloromethyl chloroformate, has a predominantly lachrymatory action, while the last, trichloro-methyl chloroformate, has an essentially asphyxiant action and practically no lachrymatory property. 

Figure 18.2.1. Chromatogram of substances emitted during degreasing. Oven temperature 40°C. 1 - benzene, 2 -2,2-dichloromethylpropane, 3 - butyl ester of formic acid, 4 - methylbenzene, 5 - water, 6 - 1-butanol, 7, 8,10, 11, 12, 13, 14 - derivatives of methyl ethyl benzene, 9 - propyl benzene.

Methyl, ethyl, n-propyl, isopropyl, n-hutyl, benzyl, cyclohexyl esters of formic, acetic, oxalic, succinic, tartaric, citric, benzoic, salicylic (and other substituted benzoic acids), phthalic and cinnamic acids phenyl esters of acetic, benzoic and salicylic acids. 

Asymmetric hydrogenolysis of allylic esters with formic acid with satisfactory ee was observed[387], Geranyl methyl carbonate (594) was reduced to 570 with formic acid using l,8-bis(dimethylamino)naphthalene as a base and MOP-Phen as the best chiral ligand, achieving 85% ee. 

A. Ethyl N- p-tolylsulfonylmethyl)carhamate,[Carbamic acid, (4 -methyl-phenylsulfonylmethyl)-, ethyl ester]. A solution of 178 g. (1.0 mole) of sodium p-toluenesulfinate (Note 1) in 1 1. of water is placed in a 3-1., three-necked daak, equipped with a condenser, an efficient mechanical stirrer, and a thermometer. After addition of 100 ml. (108 g.) of a 34—37% solution of formaldehyde ca. 1.2-1.4 moles) (Note 2), 107 g. (1.2 moles) of ethyl carbamate (Note 3), and 250 ml. of formic acid (Note 4), the stirred solution is heated to 70°. Soon after this temperature is reached, the reaction mixture becomes turbid by separation of the... 

James, A. T. and Martin, A. J. P. 1956. Gas-liquid chromatography The separation and identification of the methyl esters of saturated and unsaturated acids from formic to n-octadecanoic acid. Biochem. J. 63, 144-152. 

In these catalyzed oxidations, formic acid production did not parallel the uptake of lead tetraacetate49 and, particularly with the D-mannopyrano-side and D-galactopyranoside, fell far short of the theoretical value of one mole per mole (see Fig. 2). Methyl a-D-mannoside yielded only one third of a mole of free acid per mole, a result which agreed well with the earlier formulation97 of the ester (XLVII) as the reaction product to be expected. The almost equally low yield of formic acid from methyl a-D-galactopyrano-... 

The reactivity of the a-methylene group in lactams allows Claisen condensation with esters of formic, oxalic, and arylcarboxylic acids. Treatment of ethyl formate with A-methylpiperidone, followed by acidification, yields a salt of 1 -methyl- J2-piperideine, whereas in an alkaline medium its dimer was isolated.34- 158 With oxalic acid ester as the condensing reagent, 1-methyl-J2-pyrroline-2-carboxylic acid159 and l-methyl-d2-piperideine-2-carboxylic acid160 were obtained (Scheme 4). 

Dimethylformamide was suggested for the GC detection of microgram amounts of formic acid [182]. After esterification of acids with diazomethane the sample was treated with a dimethylamine—water mixture (1 2). Dimethylformamide was thus produced from formic acid ester, while other acids present were analysed as methyl esters. 

The reductive methylation of amines with formaldehyde in the presence of formic acid. See Lindeke, B., Anderson, B., and Jenden, D.J., Specific deuteromethylation by the Eschweiler-Clark reaction. Synthesis of differently labelled variants of trimethylamine and their use of the preparation of labelled choline and acetylcholine, Biomed. Mass Spectrom. 3, 257-259, 1976 Boldavalli, E, Bruno, O., Mariani, E. et al.. Esters of A-methyl-iV-(2-hydroxyethyl or... 

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