Stage method

Protein Polymer and molecular weight Degree of amino group substitution and linkage method Stage in Clinical Trials Ref. 

By the beginning of 1990, the reactions in Scheme 10 had mostly reached the Method stage of development (see Chapter 8 for the definition of Method). In short, considerable process development and scale-up work, in collaboration with manufacturing and others, was still needed to create a process. 

The traditional method stages of preparation of cuvee, fermentation and aging, riddling and disgorging, already have been explained. The specific processes as used by two wineries will be given to illustrate differences in operation. 

E j Net energy gain by a phase in a nonequilibrium method, stage,/,... 

Kfy K-value for base component of the K6 method and the simple K-value model of the inside-out methods, stage / Sec. 4.2.10. 

The method described by Hou et al. (2005) utilizes a series of pH or concentration controlled precipitations for the purification of Ca, with 7 method stages, including the chemical recovery determination. The determination of Sr, however, involves a further 3 chemical separation steps, and a further 3 weeks for a result. Decontamination factors are > 10 for Eu, Cs, Sr, Fe, Ni, Co. 

Clearly, the time chart shown in Fig. 4.14 indicates that individual items of equipment have a poor utilization i.e., they are in use for only a small fraction of the batch cycle time. To improve the equipment utilization, overlap batches as shown in the time-event chart in Fig. 4.15. Here, more than one batch, at difierent processing stages, resides in the process at any given time. Clearly, it is not possible to recycle directly from the separators to the reactor, since the reactor is fed at a time different from that at which the separation is carried out. A storage tank is needed to hold the recycle material. This material is then used to provide part of the feed for the next batch. The final flowsheet for batch operation is shown in Fig. 4.16. Equipment utilization might be improved further by various methods which are considered in Chap. 8 when economic tradeoffs are discussed. 

Distillation is by far the most commonly used method for the separation of homogeneous fluid mixtures. No attempt should be made to optimize pressure, reflux ratio, or feed condition of distillation in the early stages of design. The optimal values will almost certainly change later once heat integration with the overall process is considered. 

Because of their diversity and complexity as well as the gradual internationalization of the different standards, it has proven necessary to standardize the methods of sample preservation, handling, fractionation, and analysis throughout the chain of separation and treatment. All these stages are the object of precise protocols established by official national and international organizations. They describe in as minute detail as possible the procedures employed not only for each analysis but very often giving different procedures for the same analysis in different matrices. These are the standards or standardized methods discussed in Chapter 7. 

Another method of maintaining production potential from the field is to drill more wells, and it is common for wells to be drilled in batches, just as the compression is added in stages, to reduce early expenditure. 

The amount of detail input, and the type of simulation model depend upon the issues to be investigated, and the amount of data available. At the exploration and appraisal stage it would be unusual to create a simulation model, since the lack of data make simpler methods cheaper and as reliable. Simulation models are typically constructed at the field development planning stage of a field life, and are continually updated and increased in detail as more information becomes available. 

Analytical models using classical reservoir engineering techniques such as material balance, aquifer modelling and displacement calculations can be used in combination with field and laboratory data to estimate recovery factors for specific situations. These methods are most applicable when there is limited data, time and resources, and would be sufficient for most exploration and early appraisal decisions. However, when the development planning stage is reached, it is becoming common practice to build a reservoir simulation model, which allows more sensitivities to be considered in a shorter time frame. The typical sorts of questions addressed by reservoir simulations are listed in Section 8.5. 

At the development planning stage, a reservoir mode/will have been constructed and used to determine the optimum method of recovering the hydrocarbons from the reservoir. The criteria for the optimum solution will most likely have been based on profitability and safety. The model Is Initially based upon a limited data set (perhaps a seismic survey, and say five exploration and appraisal wells) and will therefore be an approximation of the true description of the field. As development drilling and production commence, further data is collected and used to update both the geological model (the description of the structure, environment of deposition, diagenesis and fluid distribution) and the reservoir model (the description of the reservoir under dynamic conditions). 

In Section 13.2, it was suggested that opex is estimated at the development planning stage based upon a percentage of cumulafive capex (fixed opex) plus a cosf per barrel of hydrocarbon production (variable opex). This method has been widely applied, with the percentages and cost per barrel values based on previous experience in the area. One obvious flaw in this method is that as oil production declines, so does the estimate of opex, which is nof the common experience as equipment ages it requires more maintenance and breaks down more frequently. 

The Direct Current Potential Drop method (DCPD) has been evaluated for non destructive testing of uniaxially produced Powder Metallurgical (P/M) parts. The aim is to adapt DCPD to be functional as an ndt tool during production of parts. Defects can occur at different stages in the production cycle which means that DCPD has to be performed on components in different states and searching for different defects. 

With this testing method an evaluation is possible within shortest time, i.e. directly after the heat impulse. The high temperature difference between a delamination and sound material is affected - among other parameters - by the thickness of the layer. Other parameters are size and stage of the delamination Generally, a high surface temperature refers to a small wall thickness and/or layer separation [4],... 

Insofar as Ultrasonic Array probes have come onto the market from several years and are now moving from prototype stages into industrial tools for on-site inspections, methods and tools for acoustic characterization is becoming a real concern. Furthermore, the lack of standards, either national or European, enhances the needs for guidelines proposal. 

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