Methicillin-resistant Staphylococcus epidermidis

Streptococcus pneumoniae Penicillin susceptible Penicillin intermediate Penicillin resistant Group B Streptococcus Staphylococcus aureus Methicillin susceptible Methicillin resistant Staphylococcus epidermidis Listeria monocytogenes... [Pg.406]

Sotozono C, Inagaki K, Fujita A, et al. Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea. Cornea 2002 21 S94-S101. [Pg.220]

MRSE methicillin-resistant Staphylococcus epidermidis PMN polymorphonuclear... [Pg.205]

Smith MA, Sorenson JA, Lowy FD. Treatment of experimental methicillin-resistant Staphylococcus epidermidis endophthalmitis with intravitreal vancomycin. Ophthalmology 1986 93 1328-1335. [Pg.355]

Joint replacement S. aureus, S. epidermidis Cefazolin 1 gx 1 preoperatively, then every 8 hours x 2 more doses Vancomycin reserved for penicillin-allergic patients or where institutional prevalence of methicillin-resistant Staphylococcus aureus warrants use IA... [Pg.541]

Nafcillin, oxacillin, cloxacillin, and dicloxacillin are more resistant to bacterial (3-lactamases than is penicillin G. Consequently, these antibiotics are effective against streptococci and most community-acquired penicillinase-producing staphylococci. Methicillin, which is no longer marketed in the United States, is another penicillinase-resistant antibiotic similar to nafcillin and oxacillin. For historical reasons, staphylococci resistant to oxacillin or nafcillin are labeled methicillin resistant. Many hospitals are reservoirs for MRSA and methi-cillin-resistant Staphylococcus epidermidis (MRSE). These nosocomial pathogens are resistant in vitro to all (3-lactam antibiotics. [Pg.529]

Steady-state peak and trough concentrations are chosen for the patient based on the site and severity of the infection, as well as the known or suspected pathogen and avoidance of potential side effects. Cmax.ss values of between 20 and 40 mg/L and C in.ss values of between 5 and 10 mg/L typically are used for patients with moderate to severe methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, or penicillin-resistant enterococcal infections. After appropriate steady-state concentrations are chosen, the dosage interval required to attain those concentrations is computed, and r is rounded to a clinically acceptable value (12, 18, 24, 36, 48, or 72 hours) r = (In Cmax.ss - In Cmin.ss)/ - Finally, the maintenance dose is computed for the patient using a one-compartment-model intravenous bolus equation at steady state, and the dose is rounded off to the nearest 100 to 250 mg ... [Pg.65]

The ferrocenyl bioconjugates of 6-aminopenicillanic acid 112 (Figure 3.7) have been evaluated for their antibacterial activity against S. aureus ATCC 29213 (MSSA, methicillin-susceptible Staphylococcus aureus), S. aureus ATCC 43300 (MRSA, methicillin-resistant Staphylococcus awrews), S. awrewsATCC 700787 (VRSA, vancomycin-resistant Staphylococcus aureus), and Staphylococcus epidermidis ATCC 12228 bacterial strains [86]. The minimum inhibitory concentration (MIC) of... [Pg.122]

PenicBlins Resistant to Pemditnase. Modification of the penicillin structure produced a group of drugs including methicillin, oxacillin, cloxacillin, dicloxacillin, and nafcillin that are not susceptible to staphylococcal penicillinase. Their appropriate use is in the treatment of infections caused by strains of Staphylococcus aureus and Staphylococcus epidermidis that produce penicillinase. These include most strains isolated from hospital settings and the general commimity. [Pg.181]

Methicillin-resistant strains of Staphylococcus aureus and S. epidermidis and penicillin-resistant Streptococcus pneumoniae have been isolated from ocular infections. Therefore treatment of ocular infections caused by these organisms might require use of vancomycin for resolution. Vancomycin is also recommended for empiric intra-vitreal and topical therapy in bacterial endophthalmitis and for parenteral therapy in moderate to severe preseptal cellulitis (see Table 11-1). [Pg.185]

Coagulase-negative staphylococci, such as Staphylococcus epidermidis, are the most common causes of catheter-related infections due to their ability to adhere to prosthetic material. Staphylococcus aureus, aerobic gramnegative bacilli, and Candida albicans are also common causes of catheter-related infections. Depending on local susceptibility patterns, methicillin-resistant S. aureus (MRSA) may represent up to 20% of all isolates. In contrast, upward of 80% of S. epidermidis are methicillin-resistant (MRSE). [Pg.122]

Ampicillin, amoxicillin Doxycycline, fosfomycin, or nitrofurantoin E. faecium (generally more resistant to antibiotics than E. faecalis) Recommend consultation with infectious disease specialist. Linezolid, quinupristin/dalfopristin Staphylococcus aureus/Staphylococcus epidermidis Methicillin (oxacillin)-sensitive PRP"... [Pg.1920]

Shore AC, Rossney AS, O Connell B, Herra CM, Sullivan DJ, Humphreys H, Coleman DC (2008) Detection of staphylococcal cassette chromosome mec-associated DNA segments in multire-sistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicilhn-resistant S. aureus and MSSA. Antimicrob Agents Chemother 52 4407-4419... [Pg.179]

Indicated only for non-methicillin-resistant strains of Staphylococcus aureus and Staphylococcus epidermidis. Compared to other penicillins, these penicillinase-resistant penicillins lack activity against Listeria monocytogenes and Enterococcus spp. [Pg.730]

Pereira, E.M., Shuenck, R.R, Malvar, K.L., et al. (2010) Staphylococcus aureus, SUqthylococcus epidermidis and Staphylococcus haemolyticus methicillin-resistant isolates are detected directly in blood cultures by multiplex PCR. Microbiol Res 165, 243—249. [Pg.31]

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