Methane sulphonate

Bromocriptine mesilate is 2-bromo-a-ergocryptine methane-sulphonate or 2-bromo-12 -hydroxy-2,-(l-methylethyl)-5 -(2-methylpropyl-5 a-ergotaman-3, 6, 18-trione methanesulphonate or Bromocriptinum (INN). It is the active ingredient in Parlodel dosage forms. 

The neomycin molecule contains both free amino and free hydroxy groups. Many workers have exploited the possibility of chemical de-rivatisation at these positions in attempts to reduce the toxicity of the parent antibiotic. Substitution of methane sulphonate groups at the amino nitrogen has been reported by Umezawa et al83,84 and by Boissier et al . Both groups of workers described the derivative to be less toxic... 

The benefits of the cerium methane sulphonic process are [132] (1) low cost, (2) methane sulphonic acid is unreactive with reactants and products, (3) stable to anodic and Ce(IV) oxidations, (4) high solubility of both Ce(III) and Ce(IV),... 

Ahmed Kabir etal. (1992) treated wood with DMDHEU as well as DMDHEU combined with a vinyl polymer, and determined the dimensional stability of the wood. Methane sulphonic acid was used as a catalyst in both cases. DMDHEU treatment resulted in a 50 % reduction in radial swelling following immersion in water for 100 minutes, with the combined treatment being snperior. However, the ASE (one cycle) of DMDHEU treated wood (30%) was snperior to that fonnd for the combined treatment (17%). DMDHEU appeared to be stable to hydrolysis over a number of wetting cycles. When DMDHEU-treated samples were exposed in ontdoor weathering trials, they exhibited considerable variation in moistnre content and developed severe surface checks, whereas the combined treatment showed snperior performance. 

Laufer, J., Karmeli, F., Rachmilewitz, D., and Scapa, . Effect of N-methylpyridinium-2-aldoxlme methane sulphonate (P2S) on rat intestinal, (Na-K)-ATPase and adenyl cyclase activities. Eur. J. Pharmacol. 74 61-66, 1981. 

Sundwall, A. Plasma concentration curves of N-methyl-pyridinium-2-aIdoxime methane sulphonate (P2S) after intravenous, intramuscular, and oral administration in man. 

Albanus, L., Jarplid, B., Sundwall, A. 1961. The chronic toxicity of N-methylpyrldlnlum-2-aldoxlme methane sulphonate (P2S), a reactivator of phosphorylated cholinesterase. Acta Pharmacol. Toxicol. 18 321-328. 

Barkman, R. 1963. The stability of pralidoxime methane sulphonate (P2S) and pralidoxime chloride (PAM Cl) in aqueous solutions. Rev. Internat. Serv. Sante7Armees Terre Mer 36(2) 9l-98. 

Tudor, R.J., Severs, N.J. Hicks, R.M. (1984) The promoting activity of methyl methane-sulphonate in rat bladder carcinogenesis. Br. J. Cancer, 50, 63-75... 

Warren, W, Clark, J.P, Gardner, E., Harris, G, Cooper, C.S. Lawley, PD. (1990) Chemical induction of thymomas in AKR mice interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of W-methyl-A-nitrosourea and methyl methane-sulphonate. Mol. Carcinog., 3, 126-133... 

FXeOSOjCF3 mw 299.37 colorl solid mp, decompn at RT if an excess of Xe difluoride is used in the prepn, the product will expld violently on warning to RT. Prepn is by reacting one mole of Xe difluoride with two moles of anhydr methane sulphonic acid initially at -110°, then completing the reaction at —63°... 

Both lyotropic and thermotropic liquid-crystalline synthetic polymers have been widely studied. Aromatic polyamides constitute the most important class forming liquid-crystalline solutions the solvents are either powerfully protonating acids such as 100% sulphuric acid, chloro-, fluoro- or methane-sulphonic acid, and anhydrous hydrogen fluoride, or aprotic dipolar solvents such as dimethyl acetamide containing a small percentage, usually 2-5 %, of a salt such as lithium chloride or calcium chloride. Such solutions constitute a nematic phase within certain limits. Some criteria for formation of a nematic instead of an isotropic phase are ... 

A one-pot PTC reaction procedure for the overall conversion of an alkyl halide into a primary amine via an azide is particularly illustrative.204 Thus the reduction of the azide is effected by the addition of sodium borohydride to a reaction mixture arising from the PTC displacement reaction of an alkyl halide with sodium azide (the preparation of 1-octylamine, Expt 5.193). The reaction appears to be applicable to primary and secondary alkyl halides, alkyl methane-sulphonates and benzylic halides. 

Grow cells on enriched media containing the mutagen A-methyl-N, -nitro-Ar-nitrosoguanidine (MNNG) at 0.5/ig/ml or ethyl methane sulphonate (EMS) at 200/tg/ml for 16 h. 

Cell monolayers are treated with the mutagenic agent ethane methane sulphonate (400/ig/ml Eastman Ltd.) and allowed to grow for 3 days. 

EFC EGF EMS ESG ETC Eagle s MEM supplemented with foetal calf serum epidermal growth factor ethyl methane sulphonate Ewing sarcoma growth factor Eagle s MEM supplemented with tryptose phosphate (10%) and calf serum (10%)... 

SYNS EMS ENT 26,396 ETHYL ESTER of METHANESULFONIC ACID ETHYL ESTER of METHYLSL LFONIC ACID ETHYL ESTER of METHYLSULPHONICACID ETHYL METHANE-SULPHONATE ETHYL METHANSULFONATE ETHYL METHANSULPHONATE HALF-MYLERAN METHYNESULPHONIC ACID ETHYL ESTER METHYLSULFONIC ACID, ETHYL ESTER NSC-26805 RCRA I tYISTE NUMBER U119... 

ISOPROPYLMETHANESULFONATE see IPY OOO ISOPROPYL METHANE SULPHONATE see IPYOOO 4-ISOPROPYL-l-METHYLBENZENE see CQIOOO ISOPROPYL 2-METHYL-2-BUTENOATE see IRNIOO ISOPROPYL a-METHYL CROTONATE see IRNIOO... 

It is obvious that this type of suppresser column will have a limited lifetime but can be regenerated rapidly and easily by passing acetonitrile through it, followed by water. An example of the use of this type of suppression system is given in figure 4. It is seen that an excellent separation of the cations was achieved and the separation was carried out with 20 nM of methane sulphonic acid present in the mobile phase which was completely removed by the ion suppresser column. 

Tetramethylcyclohexanes.—An improved method for the preparation of j3-cyclocitral in purer form has been described. The methylsulphonate of a-cyclogeraniol (188) forms the cyclopropane derivative (189) with calcium carbonate, and this rearranges to a bicyclo[3,l,l]heptanol (190) with methane-sulphonic acid. Bohlmann and Zdero have found that the angelic acid ester of... 

Application of the method to the determination of the dihydroergotoxine alkaloids in commercial samples and pharmaceutical preparations were all carried out with the free base of the alkaloids since analysis of their salts cannot be performed without excessive decomposition. The mean dihydroergotoxine methane sulphonate content of five commercial samples was 95,2 2.9 %, including a mean dihydroergocomine content of 30.9 0.8 %, a mean dihydro-ergokryptine content of 32.8 2.1 % and a mean dihydroergocristine content of 31.5 3.5 %. Almost the same data were observed for dihydroergotoxine tablets obtained from two manufacturers. 

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