Metabolite isolation and identification

Improved methods and instrumentation for metabolite isolation and identification, such as capillary GC, GC/MS, HPLC, high field NMR, FAB/MS, CI/MS, FT-IR and HPLC/MS have made the identification of new or unusual metabolites more practical. As these advanced techniques are employed to study xenobiotic metabolism in more diverse species of plants, additional classes of xenobiotics will no doubt be discovered. 

See also Drug Metabolism Metabolite Isolation and Identification Isotope Studies. Pharmacokinetics Absorption, Distribution, and Elimination Pharmacodynamics. 

Figure 3 A schematic representation of sample preparation, metabolite isolation, and identification using modern analytical Figure 4 A computational approach for metabolite identification instruments. during drug metabolism studies.

Nnane IP, Damani LA, and Hutt AJ (1995) Dmg metabolism studies Metabolite isolation and identification. In Townsend A, Worsfold PJ, Haswell SJ, Macrae R, Werner HW, and Wilson ID (eds.) Encyclopedia of Analytical Science, vol. 2, pp. 944—951. London Academic Press. 

See also Air Analysis Sampling. Chromatography Overview Principles. Clinical Analysis Sample Handling. Drug Metabolism Metabolite Isolation and Identification. Extraction Solid-Phase Extraction. Food and Nutritional Analysis Sample Preparation. Forensic Sciences Volatile Substances. Headspace Analysis Purge and Trap. Perfumes. Sample Handling Sample Preservation Automated Sample Preparation. Sampling Theory. 

See also Drug Metabolism Metabolite Isolation and Identification. Nuclear Magnetic Resonance Spectroscopy Instrumentation. Nuclear Magnetic Resonance Spectroscopy-Applicable Elements Hydrogen Isotopes. Nuclear Magnetic Resonance Spectroscopy Applications Pharmaceutical. Nuclear Magnetic Resonance Spectroscopy Techniques Multidimensional Proton Surface Coil In Vivo Spectroscopy Using Localization Techniques. Polymers Synthetic. 

See also Bioassays Overview. Drug Metabolism Metabolite Isolation and Identification. Infrared Spectroscopy Ovenriew. Liquid Chromatography Liquid Chromatography-Nuclear Magnetic Resonance Spectrometry Pharmaceutical Applications. Mass Spectrometry ... 

See also Archaeometry and Antique Analysis Dating of Artifacts. Bioassays Ovenriew. Drug Metabolism Metabolite Isolation and Identification Isotope Studies. Fertilizers. Food and Nutritional Analysis Meat and Meat Products. Immunoassays, Techniques Radioimmunoassays. Isotope Dilution Analysis. Pesticides. Pharmaceutical Analysis Drug Purity Determination. Process Analysis Overview. Radiochemical Methods Pharmaceutical Applications. Water Analysis Industrial Effluents. 

---