Metabolic engineering Corynebacterium glutamicum

Heider, S.A., Peters-Wendisch, P., Netzer, R., Stafhes, M., Brautaset, T., and Wendisch, V.F. (2014) Production and glucosylation of C50 and C 40 carotenoids by metabolically engineered Corynebacterium glutamicum. Appl. Microbiol Biotechnol, 98 (3), 1223-1235. 

Y, and Woo, H.M. (2014) Biosynthesis of pinene from glucose using metabolically-engineered Corynebacterium glutamicum. Biotechnol. Lett, 36 (10), 2069-2077. 

Okino, S., Noburyu, R., Suda, M., Jojima, T. et al (2008) An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain. Appl. Microbiol Biotechnol, 81, 459-464. 

SA production in metabolically engineered Corynebacterium glutamicum AWh-pCRA717 strain under oxygen-deprived condition. Native pyruvate carboxylase (pyc) was overexpressed and lactate dehydrogenase [idh) was disrupted in this strain. X indicates knocked-out gene. Black line indicates overexpression. PEP, phosphoenolpyruvate OAA, oxaloacetate MAL, malate FUM, fumarate ... 

Jojima, T., Fujii, M., Mori, E., Inui, M., and Yukawa, H. (2010) Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino... 

Sahm H, Eggehng L, de Graaf AA. (2000) Pathway analysis and metabolic engineering in Corynebacterium glutamicum. Biol Chem 381 899-910. 

Becker J, Klopprogge C, Herold A et al (2007) Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum-over expression and modification of G6P dehydrogenase. J Biotechnol 132 99-109... 

Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum 23... 

Table 3 Metabolic engineering of Corynebacterium glutamicum for biotechnological applications. The papers listed comprise either review papers summarizing the progress achieved or recent key contributions.

Koffas, M.A. Jung, G.Y. Stephanopoulos, G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab. Eng. 2003, 5 (1), 32-41. 

R521 H. Sahm, L. Eggeling and A. A. De Graaf, Pathway Analysis and Metabolic Engineering in Corynebacterium Glutamicum , Biol. Chem., 2000,381, 899... 

Metabolic Engineering for L-lysine Production by Corynebacterium glutamicum... 

Amino acids, citric acid, lactic acid, propanediol, penicillin G, synthetic drug intermediates, and therapeutic proteins are among the industrially relevant products of fermentation and cell culture that have been targets for metabolic engineering. Some ofthis work has been adopted by industry (see [72], section 16.4.1). The major aim was to optimize the yields of industrial products, which was efficiently realized with Corynebacterium glutamicum for lysine and tryptophan, and at the Dupont company for 1,3-propane diol production [107-109]. 

Neuner, A. and Heinzle, E. (2011) Mixed glucose and lactate uptake by Corynebacterium glutamicum through metabolic engineering. Biotechnol /, 6 (3), 318-329. 

Eikmanns, B.J. and Blombach, B. (2014) The pyruvate dehydrogenase complex of Corynebacterium glutamicum an attractive target for metabolic engineering. / BiotechrwL, 192, 339 - 345. 

Becker, ]., Zelder, O., Haefner, S., Schroder, H., and Wittmann, C. (2011) From zero to hero - design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metab. Eng., 13 (2), 159-168. 

C. (2013) Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway - metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum. Metab. 

Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine. Microb. Cell Fact., 12 (1), 110. 

Kind, S., Jeong, W.K., Schroder, H., and Wittmaim, C. (2010) Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for biobased production of diaminopentane. 

M. (2012) Toward homosuccinate fermentation metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate fi-om glucose and formate. Appl Environ. Microbiol., 78 (9), 3325-3337. 

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