Meningitis case study

Some rarer adverse effects, such as aseptic meningitis, have been reported with ibuprofen, suhndac, and tolmetin (37) in patients with systemic lupus erythematosus. A case-control study showed no increased risk of intracerebral hemorrhage in patients using aspirin or other NSAIDs in low dosages as prophylaxis against thrombosis (43). 

Type 1 fimbriae have a well established role in UTI [98], and have also been implicated in neonatal meningitis [99], Crohn s disease [100, 101], and bovine mastitis [102-106], Their involvement in UTI pathogenesis has been extensively studied. UTIs are believed to affect at least 50% of women in the western world over their lifetime. Each year, 150 million UTIs have been estimated to occur worldwide. The most common cause of UTI in humans is UPEC infection, accounting for about 80% of reported cases. UPEC-caused UTI is also common in animals, e.g. cats and dogs [107],... 

The interaction between rifampicin and fluconazole appears to be established and of clinical importance. Although rifampicin has only a modest effect on fluconazole, the cases of relapse cited above and the need for an increased dosage indicate that this interaction can be clinically important. Monitor concurrent use and increase the fluconazole dosage if necessary. One study suggests a 30% increase in fluconazole dose may be considered for serious infections during concurrent rifampicin therapy. This may be especially important during prophylaxis of cryptococcal meningitis with lower doses of fluconazole, such as 200 mg daily. ... 

A study in 264 patients (adults, and children over two months old) with acute bacterial meningitis showed that when they were given ampicillin 150 mg/kg daily alone, the case-fatality ratio was 4.3% compared with 10.5% in comparable subjects given a combination of ampicillin, chloramphenicol 100 mg/kg daily up to 4 g and streptomycin 40 mg/kg daily up to 2 g. The neurological sequelae (hemiparesis, deafness, cranial nerve palsies) were also markedly increased by the combined use of these drugs. Antibacterial antagonism was clearly seen in a 10-week-old infant with Salmonella enteritidis meningitis, who was treated with chloramphenicol and ceftazidime. ... 

First clinical studies with 5-fluorocytosine have been reported. Doses of 100 mg/1 per day for as long as 87 days were administered orally to ten patients with severe candidosis. Cures or a favorable response were achieved in more than half the cases. No toxic symptoms were observed. Sixteen patients with cryptococcal meningitis were treated with 4 to 6 g per day for 30 to 111 days. Cures were achieved in half the cases. Toxic symptoms were not serious. The drug proved ineffective in experimental coccidioidomycosis in mice." ... 

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