Meningitis aseptic

Neurologic symptoms (meningoencephalitis, aseptic meningitis, peripheral neuropathy, facial palsy, or cognitive impairment or psychosis)... 

CDC Case Definition Arboviral infections may be asymptomatic or may result in illnesses of variable severity sometimes associated with central nervous system (CNS) involvement. When the CNS is affected, clinical syndromes ranging from febrile headache to aseptic meningitis to encephalitis may occur, and these are usually indistinguishable from similar syndromes caused by other viruses. Arboviral meningitis is characterized by fever, headache, stiff neck, and pleocytosis. Arboviral encephalitis is characterized by fever, headache, and altered mental status ranging... 

Aseptic meningitis (fever, headache, photophobia, and stiff neck) may be present in a one-fourth of presenting cases Other... 

After incubation, initial clinical manifestations include fever, cough, chills, myalgia, headache, and sometimes pleuritic chest pain. Approximately 50% of patients show abnormal chest x-rays patchy infiltrates resemble viral disease. Uncommon complications include endocarditis, hepatitis, aseptic meningitis, encephalitis, and osteomyelitis. Most patients who develop endocarditis have preexisting valvular heart disease.3... 

Aseptic meningitis Aseptic meningitis with fever and coma has been observed on rare occasions in patients on NSAIDs therapy, although it is probably more likely to occur in patients with SLE. 

Neuropsychiatric events Seizures, encephalopathy, cerebral edema, aseptic meningitis, and headaches have occurred during therapy with muromonab-CD3, even following the first dose, resulting in part from T-cell activation and subsequent systemic release of cytokines. 

Aseptic meningitis syndrome-The incidence of this syndrome was 6%. Fever, headache, meningismus, and photophobia were the most commonly reported symptoms a combination of these 4 symptoms occurred in 5% of patients. Headache - Headache is frequently seen after any of the first few doses and may occur in any of the aforementioned neurologic syndromes or by itself. Seizures - Seizures, some accompanied by loss of consciousness or cardiorespiratory arrest, or death, have occurred independently or in conjunction with any of the neurologic syndromes described below. Patients predisposed to seizures may include those with the following conditions Acute tubular necrosis/uremia fever infection a precipitous fall in serum calcium fluid overload hypertension hypoglycemia, history of seizures and electrolyte imbalances those who are taking a medication concomitantly that may, by itself, cause seizures. 

An increased IgA index is found in aseptic meningitis in 40% of cases and in herpes encephalitis in almost 100% of cases as a result of virus-specific IgA antibody production. In neuromberculosis, an increased IgA index is often accompanied by normal IgC and IgM indices (LI). 

KIO. Kostic, A., VujoSevic, M., Svirtlih, N., and Kanjuh, B., Cerebrospinal fluid immunoglobulins in acute aseptic meningitis and meningoencephaUtis. Period. Biol. 81, 477-480 (1979). 

Adverse effects that are not unequivocally related to inhibition of prostaglandin synthesis include hepatic effects (hepatitis, hepatic necrosis, cholestatic jaundice, increased serum aminotransferases), dermal effects (photosensitivities, Stevens-Johnson syndrome, toxic epidermal necrolysis, onycholysis), central nervous system (CNS) effects (headaches, dizziness, tinnitus, deafness, drowsiness, confusion, nervousness, increased sweating, aseptic meningitis), ocular effects (toxic amblyopia, retinal disturbances), and certain renal effects (acute interstitial nephritis, acute papillary necrosis). 

Neuropsychiatric events, including seizures, encephalopathy, cerebral edema, aseptic meningitis, and headache... 

Although aseptic meningitis has been associated with the use of radioactive iodine, the products used were albumin complexes (131I-RISA) this complication is almost certainly attributable to the protein content or to pyrogens rather than to the radioactive iodine itself (8). 

Sjogren s syndrome is occasionally complicated by systemic vasculitis, causing focal cerebral ischemia, global encephalopathy and aseptic meningitis (Hietaharju et al. 1993 Bragoni et al. 1994 Delalande et al 2004). 

Acute posterior multifocal placoid pigment epitheliopathy is a rare and usually benign and self-limiting chorioretinal disorder, with rapidly deteriorating central vision. However, it can be complicated by systemic vasculitis, aseptic meningitis and stroke (Cornu et al. 1996 de Vries et al. 2006). 

Beta amyloid immunization was initiated in humans after the successful studies in rodents. Phase I studies were completed without major adverse events and Phase II trials were initiated with AN 1792 (active immunization with amyloid beta 42 and QS-21 adjuvant). The trials were interrupted in 2002 because approximately 6% of those vaccinated developed aseptic meningitis (Orgogozo et al., 2003). Data from the incomplete trial suggest that AD patients who mounted a significant antibody response also showed signs of clinical benefit (Orgogozo et al., 2003 Hock et al., 2003). Autopsy findings from three patients who died approximately 1 year... 

Cooper, J.F. Harbert, J.C. Endotoxin as a cause of aseptic meningitis after radionuclide cisternography. J. Nucl. Med. 1975, 16, 809-813. 

A 60-year-old man developed aseptic meningitis after taking allopurinol on two separate occasions (5). 

Greenberg LE, Nguyen T, Miller SM. Suspected allopurinol-induced aseptic meningitis. Pharmacotherapy 2001 21(8) 1007-9. 

Aseptic meningitis occurred in a patient with pre-existing Sjogren s syndrome and the drug link was confirmed by positive rechallenge (45). 

A case of aseptic meningitis after intrathecal administration of baclofen has been reported but, as viral causes could not be ruled out, the causative role of baclofen was unclear (8). 

Aseptic meningitis reversible on drug withdrawal has been described at least three times (17). 

A 66-year-old woman had several episodes of recurrent aseptic meningitis associated with cefalexin, cefazolin, and ceftazidime (29). Intrathecal ceftazidime-specific IgG antibodies were isolated and a skin test with cefazolin provoked recurrence of the aseptic meningitis. 

Creel GB, Hunt M. Cephalosporin-induced recurrent aseptic meningitis. Ann Neurol 1995 37(6) 815-17. 

---