Proving of drugs

Many problems are involved in proving of drags. Potential provers may not be all perfectly healthy and their responses to a particular drag or to a particular dose of the drag are likely to vary. Royal (1991) has discussed about the problems and protocols of proving in a paper. 

Some recent studies on provings were conducted in a systematic way (Walach, 1997, Goodyear et al., 1998). Dantas and Fisher (1998) reviewed the works on provings and suggested procedures for qualitative improvement of this kind of study. 

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