T-Cell Memory

HIV produces profound CD4 depletion, possibly through initial massive depletion of gut-associated memory T-cells, followed by chronic immune activation, leading to fatigue of homeostatic T-cell responses and progressive immunodeficiency (McArthur et al. 2005). 

CD45RO Known to be the isoform of leukosialin present on memory T cells CD46 Known to be z membrane cofactor protein... 

CCR9 Memory T cells, B cells, immature thymocytes TECK/CCL25 Yes ND... 

The validity of this division within memory populations has been supported by descriptions of two populations of CD4+ memory T cells in mice, one found in lymph nodes and producing high levels of IL-2 in response to antigen... 

Skin CCR4 Homing of effector/memory T-cells... 

Campbell JJ, Murphy KE, Kunkel EJ, et al. CCR7 expression and memory T cell diversity in humans. J Immunol 2001 166 877-884. 

Sallusto F, Langenkamp A, Geginat J, Lanzavecchia A. Functional subsets of memory T cells identified by CCR7 expression. Curr Top Microbiol Immunol 2000 251 167-171. 

Rivino L, Messi M, Jarrossay D, Lanzavecchia A, Sallusto F, Geginat J. Chemokine receptor expression identifies Pre-T helper (Th)l, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells. J Exp Med 2004 200 725-735. 

Unsoeld H, Krautwald S, Voehringer D, Kunzendorf U, Pircher H. Cutting edge CCR7+ and CCR7 memory T cells do not differ in immediate effector cell function. J Immunol 2002 169 638-641. 

Unsoeld H, Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol 2005 79 4510-4513. 

Song K, Rabin RL, Hill BJ, et al. Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans. Proc Nad Acad Sci U S A 2005 102 7916-791621. 

Andrew DP, Ruffing N, Kim CH, et al. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Thl and Th2 potential. J Immunol 2001 166 103-111. 

Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets function, generation, and maintenance. Annu Rev Immunol 2004 22 745-763. 

Gattomo M, Prigione I, Morandi F, et al. Phenotypic and functional characterisation of CCR7+ and CCR7 CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis. Arthritis Res Ther 2005 7(2) R256-267. 

Fitzhugh DJ, Naik S, Gonzalez E, Caughman SW, Hwang ST. CC chemokine receptor 6 (CCR6) is a marker for memory T cells that arrest on activated human dermal micro vascular endothelium under shear stress. J Invest Dermatol 2000 115(2) 332. 

Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005 17(3) 326-332. 

Glaser, R. et al., Stress and the memory T-cell response to the Epstein-Barr virus in healthy medical students, Health Psychol., 12, 435, 1993. 

In vitro TGN1412 caused a profound, polyclonal T-cell proliferation of human peripheral blood mononuclear cells, including those from patients with BCLL. It also induced a profound activation and proliferation of T-cell subsets including CD4+ and CD8+ T cells, naive and memory T cells, and regulatory T cells. TGN1412 was shown to induce a transient, well tolerated expansion of T cells in nonhuman primates treated with TGN1412 and efficacy was demonstrated in a rhesus monkey collagen-induced arthritis model. 

Schnittmann, S. M., Lane, H. C., Greenhouse, J., and Fauci, R. S., Preferential infection of CD4 + memory T cells by human immunodeficiency virus-infected individuals. Proc. Natl. Acad. Sci. USA 87, 6058-6062 (1990). 

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