Memory lorazepam

Vermeeren A, Jackson JL, Muntjewerff ND, et al Comparison of acute alprazolam (0.25, 0.50 and 1.0 mg) effects versus those of lorazepam 2 mg and placebo on memory in healthy volunteers using laboratory and telephone tests. Psychopharmacology (Berl) 118 1-9, 1995... 

Bishop KI and Curran HY (1995). Psychopharmacological analysis of implicit and explicit memory A study with lorazepam and the benzodiazepine antagonist flumazenil. Psychopharmacology, 121, 267-278. 

Nevertheless, the GABAergic properties of benzodiazepines remain their most important clinical application. Over the past 30 years, the most widely used benzodiazepine drug has been diazepam (1.6). It is an anxiolytic, sedative, and muscle relaxant the anxious, depressed person becomes more outgoing and relaxed. There have been many diazepam analogs. Oxazepam (4.177) and lorazepam (4.178) have similar effects. Temazepam (4.179), flunitrazepam (4.180), and flurazepam (4.181) are useful sedative-hypnotics. Clonazepam (4.182) is a clinically useful anticonvulsant. Brotizolam (4.183), a novel benzodiazepine analog, seems to be an effective sedative-hypnotic. Midazolam (4.184) is an imidazolo-benzodiazepine that is water soluble and thus easily injectable. It is a hypnotic sedative with marked amnestic (i.e., memory loss) properties and is used in dentistry, endoscopic procedures, and induction to anesthetics in the elderly and in... 

Curran, H.Y., Pooviboonsuk, P., Dalton, JA., Lader, M.FL Differentiating the effects of centrally acting drugs on arousal and memory an event-related potential study of scopolamine, lorazepam and diphenhydramine. Psvchopharmacologv 135. 27-36. 1998. 

Healy M, Pickens R, Meisch R, et al. Effects of do raze pate, diazepam, lorazepam, and placebo on human memory. J Clin Psychiatry 1983 44 436-439. 

Roth T, Hartse KM, Saab PG, et al. The effects of flurazepam, lorazepam, and triazolam on sleep and memory. Psychopharmacology 1980 70 231-237. 

Bishop, K.I., Curran, H.V., and Lader, M., Do scopolamine and lorazepam have dissociable effects on human memory systems A dose-response study with normal volunteers, Exp. Clin. Psychopharmacol., 4, 292, 1996. 

Curran, H.V., Schifano, F., and Lader, M., Models of memory dysfunction A comparison of the effects of scopolamine and lorazepam on memory, psychomotor performance and mood, Psychopharmacology, 103, 83, 1991. 

Mintzer, M.Z. and Griffiths, R.R., Lorazepam and scopolamine a single-dose comparison of effects on human memory and attentional processes, Exp. Clin. Psychophatmacol., 11, 56, 2003. 

Matthews, A., Kirkby, K.C., and Martin, F., The effects of single-dose lorazepam on memory and behavioural learning, J. Psychophatmacol, 16, 345, 2002. 

Alprazolam (Xanax), lorazepam (Ativan), and oxazepam (Serax) are metabolized and cleared from the body more quickly than the other members of this family, and are therefore more likely to produce withdrawal symptoms when they are discontinued. These three drugs, however, are less likely to produce side effects such as impaired coordination, concentration, and memory and muscular weakness or sedation. 

Patat A, Perault MC, Vandel B, Ulliac N, Zieleniuk I, Rosenzweig P. Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers. Br J Clin Pharmacol 1995 39(l) 31-8. 

The psychomotor and amnesic effects of single oral doses of lorazepam 2 mg were studied in 48 healthy subjects in a double-blind, placebo-controlled, randomized, parallel-group study (9). The effects were assessed by a battery of subjective and objective tests that explored mood and vigilance, attention, psychomotor performance, and memory. Vigilance, psychomotor performance, and free recall were significantly impaired by lorazepam. 

Lorazepam shares with other benzodiazepines the ability to impair explicit memory, but has a distinct further effect on implicit memory as well (10). However, it impairs memory more than its chemically and kinetically similar analogue, oxazepam (11). The effects of lorazepam 2.5 mg and diazepam 0.3 mg/kg on explicit and implicit memory tasks have been examined in 24 men and 24 women randomly allocated to lorazepam, diazepam, or placebo (10). An implicit word-stem completion task and explicit memory tasks of immediate and delayed word recall and word recognition were administered 90 minutes after drug administration. Both diazepam and lorazepam significantly impaired performance on explicit memory measures. Only lorazepam significantly impaired performance on the implicit memory task. 

The effects of lorazepam and diazepam on false memories and related states of awareness have been investigated in 36 healthy volunteers, randomly assigned to one of three groups (placebo, diazepam 0.3 mg/kg, lorazepam... 

When co-administered with lorazepam 0.4 mg, moxonidine increased impairment of attentional tasks (choice, simple reaction time and digit vigilance performance, memory tasks, immediate word recall, delayed word recall accuracy, and visual tracking). These effects should be considered when moxonidine is coadministered with lorazepam, although they were smaller than would have been produced by a single dose of lorazepam 2 mg alone (26). 

Le Roi S, Kirby KC, Montgomery IM, Daniels BA. Differential effects of lorazepam and diazepam on explicit and implicit memory. Aust J Psychopharmacol 1999 9 48-54. 

In 30 subjects who were given an acute dose of oxazepam 30 mg, lorazepam 2 mg, or placebo, both drugs impaired explicit memory relative to placebo. Also, both oxazepam and lorazepam impaired priming performance. The results suggested that episodic memory is time-dependently impaired by both benzodiazepines (4). 

Buffett-Jerrott SE, Stewart SH, Teehan MD. A further examination of the time-dependent effects of oxazepam and lorazepam on implicit and explicit memory. Psychopharmacology (Berl) 1998 138(3 t) 344-53. 

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