Membrane lipids composition

Clejan, S., T. A. Krulwich, K. R. Mondrus, and D. Seto-Young. 1986. Membrane lipid composition of obligately and facultatively alkalophilic strains of Bacillus spp. J. Bacteriol. 168 334—340. 

Membrane lipid composition -hydrophobic matching and interfacial charges-... 

Bogdanov, M., Heacock, P. N. and Dowhan, W. (2002). A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition, EMBOJ., 21, 2107-2116. 

Hazel, J.R. (1979). Influence of thermal acclimation of membrane lipid composition of rainbow trout. American Journal of Physiology 236,91-101. 

Hazel J. R. and Williams E. E. (1990) The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment. Progress in Lipid Research 29, 167-227. 

Engelhard, V.H., Esko, J.D., Storm, D.R., and Glaser, M., Modification of adenyl cyclase activity in LM cells by manipulation of the membrane lipid composition in vivo, Proc. Natl Acad. Sci., 73, 4482, 1976. 

Carey, C. and J.R. Hazel (1989). Diurnal variation in membrane lipid composition of Sonoran desert teleosts. J. Exp. Biol. 147 375-391. 

Neelands, P.J., and M.T. Clandinin (1983). Diet fat influences liver plasma-membrane lipid composition and glucagon-stimulated adenylate cyclase activity. Biochem. J. 212 573-583. 

Robertson, J.C., and J.R. Hazel (1999). Influence of temperature and membrane lipid composition on the osmotic water permeability of teleost gills. Physiol. Biochem. Zool. 72 623-632. 

Component (percent of weight of membrane) Lipid Composition (percent of total lipid)t ... 

Membrane Lipid composition modification Increased liposome stability,... 

An obvious hypothesis is that this unusual membrane lipid composition is related directly to membrane function in some way. Within the restricted area of lipid bilayers, lipid composition is known to be an important determinant of physical properties. There are several prominent examples. First, the temperature at which the hydrocarbon chains melt when assembled in bilayers (the gel-to-liquid-crystalline transition temperature, marks an abrupt change in many of the physical properties of such bilayer systems for example, water permeability through such bilayers increases by several orders of magnitude above the transition. Second, the presence of cholesterol within bilayers composed of amphipathic lipids has a profound effect on lipid motion, mechanical properties (such as resistance to shear), and permeability to water. 

McElhaney RN. The influence of membrane lipid composition and physical properties on membrane structure and function in Acholeplasma laidlawii. CRC Crit. Rev. Microbiol. 1989 17 1-32. 

Hsiao LL, Howard RJ, Aikawa M, Taraschi TF. Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum. Biochem. J. 1991 274 121-132. 

Forrester JS, Milne SB, Ivanova PT, Brown HA. Computational lipidomics a multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction. Mol. Pharmacol. 2004 65 813-821. 

Comprehensive studies of the dependence of the relative magnitude of the dipole potential on the membrane lipidic composition have been reported previously and a summary is reported in ref. 15. Of quite some interest, however, is the possibility that di-8-ANEPPS may be used to indicate the interactions of some macromolecules with membranes as shown in Fig. 5b (lower RHS graph) and we were able to show that the dipole potential also has an effect on the structure of the peptide within the membrane (16). It appears from our findings that the magnitude of ( )d is measurably influenced by peptides/proteins that insert (at least partially) into the membrane and just as importantly vice versa. 

Pruitt NL. Membrane lipid composition and overwintering strategy in thermally acclimed crayfish. Am. J. Physiol. 1988 254 43. 

Hamm, M. W, Sekowski, A., and Ephrat, R. (1988). Dietary fat ratios and liver plasma membrane lipid composition. Lipids 23, 829-833. 

It has been postulated that Pgp acts as a so-called vacuum cleaner (49), moving compounds from the lipid bilayer into the extracellular space. A second hypothesis has been postulated where the transporter acts as a flippase (50), either moving the substrate from the inner to the outer leaflet of the membrane or locally altering membrane lipid composition such that the substrate detaches. These mechanisms support the observation that Pgp effluxes amphipatic peptides, proteins lacking signal sequences, or lipid-modified proteins from biological membranes (51). 

Bailey AL, Cullis PR (1997) Membrane fusion with cationic liposomes effects of target membrane lipid composition. Biochemistry 36 1628-1634... 

Increased acid tolerance correlates strongly with a decrease in proton accumulation in the cytoplasm. This altered proton permeability is again associated with changes in the protein composition of the cell membranes. Acid-adapted E. coli changes the lipid composition of its membranes, and elevated levels of cyclopropane fatty acids are often found. This may mean that changes in the protein composition of the cell membrane are a result of changes in the membrane lipid composition. Both lipid and protein alterations may be necessary to protect a bacterial cell in acidic environments (Jordan, Oxford, and O Byrne, 1999). 

Yuk, H.G. and Marshall, D.L. 2005. Influence of acetic, citric and lactic acids on Escherichia coli 0157 H7 membrane lipid composition, verotoxin secretion, and acid resistance in simulated gastric fluid. Journal of Food Protection 68 673-679. 

Popp-Snigders C, Shouten JA, Van Blitterswijck WJ, Van der Veen EA. Changes in membrane lipid composition of human erythrocytes after dietary supplementation of (n-3) polyunsaturated fatty acids. Biochim Biophys Acta 1986 854 31-37. 

The control of body fluid, sodium, and energy homeostasis is fundamental to mammalian life. The mechanisms involved are complex and rely heavily on receptor-mediated events. Given the ubiquity of n-3 fatty acids in mammalian cell membranes and the reliance of receptor protein activity on membrane lipid composition, we felt it timely to review the mechanisms responsible for body fluid, sodium, and energy homeostasis and to examine evidence suggesting modulation of these processes by n-3 polyunsaturated fatty acids (n-3 PUFAs). 

The variability in these results may be due to the different membrane lipid composition of the oocytes as well as differences in maturation and folding events. " Even nAChRs found in mammalian cell lines differ from native receptors. Interactions with other membrane proteins, adapter proteins, or cytoskeletal elements, which may not be present or sufficientiy expressed in the nonneuronal oocytes, may be important in modulating receptor activity... 

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