Melioidosis Burkholderia

Melioidosis B (Burkholderia pseudomallei) Animals— ho ses, mules, donkeys soil Typically 14 days Unlikely Standa d High fever, sweating, muscle pain, pleuritic chest pain, generalized skin eruptions 5-9 days in treated pts Ceftazidime, imipenem, meropenem... 

Melioidosis (or Whitmore s disease) is predominately a disease of tropical climates, especially in South-East Asia where it is endemic. The bacteria Burkholderia pseudomallei causing melioidosis is found in contaminated water and soil and are spread to humans and animals through direct contact with the contaminated source (e.g. bare food working in a rice held). 

The diagnosis is made by isolating Burkholderia pseudomallei from the blood, urine, sputum, or skin lesions through conventional culture or by PCR. Illness from melioidosis can be categorized as acute or localized infection, acute pulmonary infection, acute bloodstream infection, and chronic suppurative infection. 

Burkholderia Pseudomonas) mallei glanders) Burkholderia Pseudomonas) pseudomallei (melioidosis)... 

Recent data in humans suggest that ELR CXC chemokines may be relevant mediators of innate immunity against common extracellular bacterial pathogens. In support of this notion, markedly elevated plasma levels of IP-10 and MIG have been detected in patients with systemic Burkholderia pseudomallei infection (melioidosis), with chemokine levels correlating with plasma IFN-ylev-... 

Melioidosis is caused by the facultative intracellular Gram-negative bacillus Burkholderia pseudomallei. The organism is closely related to B. mallei (glanders), although the disease is distinctive in a number of ways. While the disease does not occur naturally in the UK, it is found in South and South-East Asia, particularly in rice paddies, in Northern Australia, Africa and Southern America. Unlike glanders, melioidosis has been known to cause human epidemics. 

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