Melanoma detection

Malvehy, J., Hauschild, A., Curiel-Lewandrowski, C., et al., 2014. CUnical performance of the Nevisense system in cutaneous melanoma detection an international, multi-centre, prospective and blinded clinical trial on efficacy and safety. Br. J. Dermatol, http //dx.doi.org/10.llll/bjd.13121. 

Human GAL1 receptor mRNA has been detected in multiple cell and tissue samples including Bowes melanoma cells, brain, gastrointestinal tract (from esophagus to rectum), heart, prostate, and testes. Rat GAL1 mRNA was detected in olfactory regions, many hypothalamic nuclei (including supraoptic nucleus),... 

Tecnemab-K-1 is used to image the extent of/presence of metastases from confirmed cases of melanoma. Tumour visualization is via radio-immunoscintigraphy and the approach is generally used in combination with additional diagnostic procedures. In clinical trials involving several hundred patients with confirmed melanoma lesions, the antibody fragments detected... 

Alterations in the gene copy number of miRNAs are detected in a variety of human cancers (41,42,43). Zhang et al. (41) showed that miRNAs exhibited high-frequency genomic alterations in human ovarian, breast cancer, and melanoma using high-resolution array-based comparative genomic hybridization. 

Four population-based case-control studies have examined associations of carbon tetrachloride with chronic lymphocytic leukaemia, brain cancer, female breast cancer and intraocular melanoma. Findings were generally unremarkable. In a fifth case-control study, which examined several cancers, no association was found with non-Hodgkin lymphoma, although the power to detect an increased risk was low. 

Fetsch, P. A., Cormier, J., and Hijazi, Y. M. 1997. Immunocytochemical detection of MART-1 in fresh and paraffin-embedded malignant melanomas. J. Immunother. 20 60-64. 

Carbohydrate tumor marker tumor-related antigen GM3 1998 A Detection level of <10 cells, melanoma cells diluted in 2 million healthy blood lymphocytes Zhang et al. [96]... 

Not only biochemical analysis, but immunohistochemical staining with antibodies against gangliosides has similarly revealed the existence and distribution of gangliosides in epidermis. Nakakuma et al. showed that epidermal keratinocytes reacted with an anti-GM3 monoclonal antibody, but not an anti-GD3 mAb.11 Expression of GM3, predominantly in the stratum corneum, was reported by Paller et al.12 In contrast, Hersey et al. detected GD2 in the basal and spinous layers of the epidermis, whereas neither GM3 nor GD3 was detected in normal skin.13 However, the epidermis adjacent to naevi and primary melanoma strongly expressed GD3.13... 

It should be recognized, however, that dysbindin-1 is not detectable in the nuclei of all cell types. Our immunohistochemical work with the PA3111 antibody noted above finds little if any dysbindin-1 immunoreactivity in the nuclei of certain neuronal populations (see Section 2.2.63.2.3). Using a similar antibody, Di Prietro et al. (2006) likewise found no dysbindin-1 in nuclei of cell of the melanoma cell line MNT-1. 

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