Melanoma cells and

Philips, N, Keller, T, Hendrix, C, Hamilton, S, Arena, R, Tuason, M, and Gonzalez, S, 2007. Regulation of the extracellular matrix remodeling by lutein in dermal fibroblasts, melanoma cells, and ultraviolet radiation exposed fibroblasts. Arch Dermatol Res 299, 373-379. 

Recently, a number of factors have been described that appear to be primarily motility factors (G3). These include scatter factor, a peptide produced by fibroblasts autocrine motility factor (AMF), a peptide originally purified from human melanoma cells and migration-stimulating factor (MSF), a peptide synthesized by embryo and certain tumor-associated fibroblasts. While both AMF... 

Chan and Murphy [64] applied a mathematical model describing the kinetics of cellnlar trafficking of monoclonal antibodies against melanoma cells, and of immnnotoxins targeted by the antibodies. The model allowed the assessment of eqnilibrinm and kinetic constants by fitting it to the data obtained from in vitro cnltnred cell experiments. 

P29 To assess the influence of Cr on the eukaryotic cells, its effect on the viability and proliferation rate of murine B16 melanoma cells, and. .. human epithelial cells was tested. (From Plaper et al, 2002)... 

Fujita, H., F. Okada, J. Hamada, M. Hosokawa, T. Moriuchi, R.C. Koya, and N. Kuzumaki. 2001. Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect. Int J Cancer. 93 773-80. 

Tumor eells ean also present by themselves new MHC elass I-restricted peptides by cross-presentation, a feature believed to be unique of dendritic cells. A peptide derived from secreted matrix metalloproteinase-2 (MMP-2) is presented by melanoma cells, and the presentation is dependent on the enzyme secretion in the extracellular space, followed by uptake of exogenous MMP-2 through endocytosis mediated by integrin avPs. The process involves transfer of MMP-2 from the endocytic compartment to the cytosol and processing by the proteasome, because presentation of this peptide was blocked by proteasome inhibitors [298]. 

IL-2 and IL-15, which uses the (3- and y-chains of the IL-2R, have been found in melanoma cells and anti-IL-15 mAbs to inhibit HLA class I expression in these cells. Therefore these cytokines may modify the behavior of both stromal and neoplastic cells inside a tumor. These data may have important implications for our understanding of tumor-host interactions and in future strategies of immunotherapy. When compared with lL-2, which enhances both spontaneous and antigen-induced lymphocyte proliferative responses, IL-15 rarely increases spontaneous lymphocyte proliferation. Thus IL-15 may help to correct the impaired profiferative response of CD4 lymphocytes from HlV-l-infected persons without the mitogenic effect of IL-2, which also may induce HIV-1 expression. "... 

Wang, Q., Zhang, J., Guo, Z. (2007). Efficient glycoengineering of GM3 on melanoma cell and monoclonal antibody-mediated selective killing of the glycoengineered cancer cell. Bioorg. Med. Chem., 15, 7561-7567. 

Li FI., Alizadeh FI., and Niederkom J. Y. (2008) Differential expression of chemokine receptors on uveal melanoma cells and their metastases. Invest Ophthalmol Vis Sci., 49, 636-43. 

Mrowietz, U., U. Schwenk, S. Maune, J. Bartels, M. Kupper, I. Fichtner, J. M. Schroder, and D. Schadendorf. 1999. The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br J Cancer 79 1025. 

Goldring, J. D., Molyneux, M. E., Taylor, T., Wirima, J., and Hommel, M. (1992). Plasmodium falciparum Diversity of isolates from Malawi in their cytoadherence to melanoma cells and monocytes in vitro. Br. ]. Haematol. 81,413-418. 

R. Decreau, M.J. Richard, P. Verrando, M. Chanon, M. Julliard (1999). Photodynamic activities of silicon phthalocyanines against achromic M6 melanoma cells and healthy human melanocytes and keratinocytes. J. Photochem. PhotobioL B. Biol., 48, 48-56. 

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