Melanoma antigen

Because of the availability of NeuAc aldolase and its unique stereochemical features, many biologically interesting molecules have been prepared. This method has been exploited, for example, in the synthesis of d- and L-sialic acid analogues (Scheme 5.31),54 in the synthesis of the polyhydroxylated alkaloid 3-(hydroxymethyl)-6-epi-castanospermine (Scheme 5.32),55 and in the synthesis of the melanoma antigen 9-0-acetyl GD3 from GD3 (Scheme 5.33).56... 

Scheme 5.33. Enzymatic synthesis of the melanoma antigen 9-O-acetyl GD3.

Kawakami Y, Nishimura MI, Restifo NP, et al. T-cell recognition of human melanoma antigens. J Immunother. 1993 14 88-93. 

Kawakami Y, Battles JK, Kobayashi T, et al. Production of recombinant MART-1 proteins and specific anti-MART-1 polyclonal and monoclonal antibodies use in the characterization of the human melanoma antigen MART-1. J Immunol Methods. 1997 202 13-25. 

Gottschalk J, Jautzke G, Schteinet C. Epithelial and melanoma antigens in gliosatcoma an immunohistochemical study. Pathol ResPract. 1992 188 182-190. 

Melanoma antigen HMB-45 Neuraminidase-sensitive oligosaccharide side chain of glycoconjugate in immature melanosomes Extract of pigmented melanoma metastases from lymph nodes Dako 1 200 HIER... 

Guler ML, Daniels JA, Abraham SC, Montgomery EA. Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors a potential diagnostic pitfall. Arch Pathol Lab Med. 2008 132 1302-1306. 

GMK vaccine is capable of producing a specific immune response against a defined and chemically purified melanoma antigen. Anti-GM2 antibodies in melanoma patients induced by the GMK demonstrate binding to melanoma cells, complement-mediated cytotoxicity, and antibody-dependent cellular cytotoxicity (54). 

Kawakami, Y., and S. A. Rosenberg. 1997. Immunobiology of human melanoma antigens MART-1 and gplOO and their use for immuno-gene therapy. Int Rev Immunol 14 173. 

Detection of AFP-mRNA and melanoma antigen gene-1 mRNA as markers of disseminated hepatocellular carcinoma cells in blood. Hepatobil Pancreat Dis Int, 4, 227—Tih. 

Parmiani G. Melanoma antigens and their recognition by T ceUs. Keio J Med 2001 50 86-90. 

Cancer-testis antigens ectopically expressed and spontaneously immunogenic in human mmors. Best examples NY-ESO (esophagus), MAGE (melanoma antigen), SSX (synovial sarcoma X chromosome breakpoint). Patients with SS developed lymphocytes cytolytic to their mmors (shown in late 1960s, text reference 147). 

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