Medicines Estrogens

Practice Committee of the American Society for Reproductive Medicine. Estrogen and progestogen therapy in postmenopausal women. Fertil Steril 2004 82 Suppl l S70-80. 

DAVIDSON M H, MAKI K C, MARX P, MAKI A C, CYROWSKI M S, NANAVATI N, ARCE J C (2000) Effects of continuous estrogen and estrogen-progestin replacement regimens on cardiovascular risk markers in postmenopausal women . Archives of Internal Medicine, 160, 3315-25. 

The estrogenic properties of isoflav-3-enes are well known and consequently, several derivatives of these chromene heterocycles have been the target of medicinal chemists. Varma and coworkers uncovered a useful enamine-mediated pathway to this class of compounds [142-144], Now the group has discovered a facile and general method for the MW-expedited synthesis of isoflav-3-enes substituted with basic moieties at the 2-position (Scheme 6.42) [145], These promising results are especially appealing in view of the convergent one-pot approach to 2-substituted isoflav-3-enes... 

Brain delivery of steroid hormones is also of interest to medicinal chemists. Again, most data available on CDSs of steroids pertain to rates of oxidation of the dihydropyridine carrier, to blood and brain concentrations, and to pharmacological activities. The latter can then be taken as proof of efficient cerebral hydrolysis of the pyridinium metabolite. Thus, the dihydrotrigonelline carrier allowed good brain delivery of estradiol and some other estrogens [181][182],... 

Synthetic steroids, especially estrogenic drugs, are used extensively in estrogen-replacement therapy and oral contraceptives, in veterinary medicine for growth enhancement, and in athletic performance enhancement. In general, large portions... 

Jordan VC. Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions. / Med Chem 2003 46 883-908. 

Approaches from medicinal chemistry that resulted in the discovery of first-and second-generation SERMS have been reviewed extensively [149] and will not be discussed in this section. The more recently published chemical structures of anti-estrogen were derived from different classes, e.g. stilbestriol. 

Ferrando, R., M. M. Guilleux, and A. Guerrillot-Venet. Oestrogen content of plants as a function of conditions of culture. Nature 1961 192 1205. Ahmad, Y. S. A note of the plants of the medicinal value found in Pakistan. Govt of Pakistan Press, Karachi 1957. Walker, B. S., and J. C. Janney. Estrogenic substances. II. An analysis of plant sources. Endocrinology... 

Steenis-Kruseman, M. ]. Van. Select Indonesian medicinal plants. Organiz Sci Res Indonesia Bull 1953 18 1. Booth, A. N., E. M. Bickoff, and G. O. Kohler. Estrogen-like activity in vegetable oils and mill by-products. Science 1960 131 1807. 

TRADITIONAL MEDICINAL USES Germany. The fruit is taken orally as a source of estrogen " . 

Ichikawa, K. et al., Retrodihydrochalcones and homoisoflavones isolated from Thai medicinal plant Dracaena loureiri and their estrogen agonist activity, Planta Med., 63, 540, 1997. 

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