Medicinal chemistry, overview

Readers interested in medicinal chemistry can obtain an excellent overview ft om the book The Practice of Medicinal Chemistry, edited by Wermuth [1]. The first edition is nicknamed The Green Bible by medicinal chemists. "The Red Bible written by Bbhm, Klebe, and Kubinyi describes the development of new drugs [2]. An overview of different classes of drugs and their mechanisms of action is given by Mutschler [3]. 

J S, I Morize, P R Menard, D L Cheney, C Hulme and R F Labaudiniere 1999. New 4-Point irmacophore Method for Molecular Similarity and Diversity Applications Overview of the thod and Applications, Including a Novel Approach to the Design of Combinatorial iraries Containing Privileged Substructures. Journal of Medicinal Chemistry 42 3251-3264. 

In the first part of the present review, new techniques of preparation of modified electrodes and their electrochemical properties are presented. The second part is devoted to applications based on electrochemical reactions of solute species at modified electrodes. Special focus is given to the general requirements for the use of modified electrodes in synthetic and analytical organic electrochemistry. The subject has been reviewed several times Besides the latest general review by Murray a number of more recent overview articles have specialized on certain aspects macro-molecular electronics theoretical aspects of electrocatalysis organic applicationssensor electrodes and applications in biological and medicinal chemistry. 

Kerns, E. H., Di, L. Physicochemical profiling overview of the screens. Drug Discov. Today Technol. 2004, 1, 343-348. Van de Waterbeemd, H. Physicochemical approaches to drug absorption. In Drug Eioavailability (Methods and Principles in Medicinal Chemistry), Van de Waterbeemd, H., Lennernas, H., Artursson, P. (eds.), Wiley-VGH, Weinheim, 2003, pp. 3-20. 

A large number of DNA-alkylating agents are known and we will not attempt a comprehensive survey here. A number of excellent reviews provide an overview of this area. " Here we will review DNA alkylation by three types of reactive intermediates that are important in medicinal chemistry and toxicology— episulfonium ions, aziridinium ions, and carbocations. 

Mason, J.S., Morize, I., Menard, P.R., Cheney, D.L., Hulme, C. and Labaudiniere, R.E. (1999) New 4-point pharmacophore method for molecular similarity and diversity applications overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures. Journal of Medicinal Chemistry, 42, 3251—3264. 

In this work, we will discuss in detail the role of HDACs as regulators of critical cellular processes, the impUcation of disregulated HDAC activity in carcinogenesis, as well as a retrospective account of the continued medicinal chemistry efforts in the field and an overview of HDAC inhibitors currently undergoing cHnical evaluation. 

In Chapter 1, John Lowe details The Role of Medicinal Chemistry in Drug Discovery in the twenty first century. The overview should prove invaluable to novice medicinal chemists and process chemists who are interested in appreciating what medicinal chemists do. In Chapter 2, Neal Anderson summarizes his experience in process chemistry. The perspectives provide a great insight for medicinal chemists who are not familiar with what process chemistry entails. Their contributions afford a big picture of both medicinal chemistry and process chemistry, where most of the readers are employed. Following two introductory chapters, the remainder of the book is divided into three major therapeutic areas I. Cancer and Infectious Diseases (five chapters) II. Cardiovascular and Metabolic Diseases (six chapters) and III. Central Nervous System Diseases (four chapters). 

The confusion between these two characteristics is common in medicinal chemistry. It comes from the usual empirical measurement of the lipophilicity, which is the logarithm of the partition coefficient between 1-octanol and water (log P). This parameter gives a representative overview of a compound absorbed by a lipidic membrane, an essential datum in medicinal chemistry. It is often considered that the higher the log P value is, the more lipophilic the compound is. Acmally, the log P value is only a measurement of relative solubility. Considering that the solubility of a fluorinated substance decreases more in water than in octanol, this measurement leads one to think that fluorinated compounds are more lipophilic. Actually, this represents the relative lack of affinity of fluorinated compounds for both phases. 

This book is intended for chemists who are interested in bioorganic and medicinal chemistry. Its aim is to give an overview of the various applications of fluorinated compounds in these areas. Bioorganic and Medicinal Chemistry of Fluorine is divided in two main parts the first one deals with generalities concerning the specific properties of fluorinated compounds and their preparation the second part is dedicated to the different classes of fluorinated compounds involved in bioorganic chemistry and to their biological properties. 

These seven groups of compounds, and the diversity of compounds within each group, are the molecular building blocks that enable structure and function. A brief overview of the relevant biochemistry for each class is pertinent to an appreciation of their role in medicinal chemistry and drug design. 

This chapter seeks to give a broad overview of medicinal chemistry. It attempts to provide a framework for the topics discussed in greater depth in the succeeding chapters. In addition, it includes some topics of general interest to medicinal chemists. 

Todeschini R, Consonni V (2000) Handbook of molecular descriptors. In Mannhold R, Kubinyi H, Timmerman H (eds), Methods and principles in medicinal chemistry 11. WILEY-VCH, Weinheim. Walters WP, Stahl MT, Murcko MA (1998) Virtual screening — and overview. Drug Discov Today 3 160—178. Ward JH (1963) Hierarchical grouping to optimize an objective function. J Am Stat Assoc 58 236—244. Warmuth MK, Liao J, Ratsch G et al. (2003) Active learning with support vector machines in the drug discovery process. J Chem Inf Comput Sci 43 667—673. 

In this chapter we have given an overview of the two major approaches used in NMR and drug discovery, structure-based design and NMR-based screening. Both areas are flourishing and, together with more traditional uses of NMR, they demonstrate the versatility of NMR as a tool in medicinal chemistry. The power of NMR has been dramatically enhanced over the last decade by developments... 

---