Privileged substructures

J S, I Morize, P R Menard, D L Cheney, C Hulme and R F Labaudiniere 1999. New 4-Point irmacophore Method for Molecular Similarity and Diversity Applications Overview of the thod and Applications, Including a Novel Approach to the Design of Combinatorial iraries Containing Privileged Substructures. Journal of Medicinal Chemistry 42 3251-3264. 

Mason JS, Morize 1, Menard PR, Cheney DL, Hulme C, Labaudiniere RF. New 4-point pharmacophore method for molecular similarity and diversity applications Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures. I Med Chem 1999 42 3251-64. 

Savchuk, N.P., Tkachenko, S.E., and Baiakin, K.V. Rational design of GPCR-specific combinatorial libraries based on the concept of privileged substructures. In Chemoinformatics in... 

Rational Design of CPCR-specific Combinational Libraries Based on the Concept of Privileged Substructures... 

In a similar manner, such privileged motifs can be identified for each GPCR-specific activity group. The typical number of privileged substructures per group lies in the range of 5 to 20 for the studied GPCR-specific compound sets. 

Horton, D.A., Bourne, G.T., and Smythe, M.L. The combinatorial synthesis of bicydic privileged structures or privileged substructures. Chem. Rev. 2003, 303, 893-930. 

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