Medication drawbacks

The starting dose of sibutramine is usually 10 to 15 mg once a day. The drawback of this drug is that, as with all medications used to treat obesity, the lost weight eventually reappears unless the patient continues to engage in healthy eating habits and an exercise program. 

Protein extraction procedures employing chemicals such as detergents are effective in many instances, but they suffer from a number of drawbacks, not least of which is that they often induce protein denaturation and precipitation. This obviously limits their usefulness. Furthermore, even if the chemicals employed do not adversely affect the protein, their presence may adversely affect a subsequent purification step (e.g. the presence of detergent can prevent proteins from binding to a hydrophobic interaction column). In addition, the presence of such materials in the final preparation, even in trace quantities, may be unacceptable for medical reasons. 

The primary medical uses of rauwolfia are antihypertensive and antipsychotic. However, it has drawbacks and its use has been supplanted with... 

It is therefore clear that consumers need to be educated about the use of such medications and reminded that OTC products can produce substantial benefits and adverse effects. All health care providers, including physical therapists and occupational therapists, need to be in a position to help educate and counsel their patients about the benefits and drawbacks of such medications. While therapists should not directly prescribe or administer OTC products, therapists can provide information about the proper use and potential benefits of these medications. 

At present, however, extrapyramidal side effects continue to be one of the major drawbacks of antipsychotic medications. The primary types of extrapyramidal side effects, the manifestations of each type, and the relative time of their onset are shown in Figure 8-2. Some factors involved in patient susceptibility and possible treatment of these side effects are discussed here. 

Blister-type multiple-dose devices. The drawbacks of gelatin capsules were overcome by GlaxoSmithKline when the Rotadisk/Diskhaler device was introduced. Rotadisk is a small blister disk containing four or eight unit doses of medication at a time. The blister provides superior protection of the medication from environmental stress such as high... 

To understand the benefits and drawbacks of opioid drugs, one needs to understand their primary effects on the body specifically, how they function as pain relievers. In the broadest sense, there are two types of pain— physical and emotional. Physical pain, while unpleasant, is necessary for survival. It serves as notification of the presence of injury or disease, which in turn prompts a person to take appropriate, possibly even life-saving action. Half of all individuals who seek medical attention report pain as their primary complaint. 

Automated dispensing devices create several situations that can easily result in errors. While these machines are routinely restocked, the wrong drug still can be placed into the wrong bin during this process. Devices that have multiple medications in each drawer and/or that do not require pharmacist review of orders before access have drawbacks that are identical to the flaws in traditional floor-stock systems ... 

The goal of Chapter 6 is to familiarize investigators in biological and medical research with mass spectrometry and its potential applications in these fields, with the anticipation that it will encourage and enable them to utilize MS in their research. An attempt has been made to provide a clear basic description of the modern mass spectrometers and of the most relevant types of experiments that they can perform. Discussed also are the advantages and drawbacks of the different methods in the context of biological research with examples of the ability of mass spectrometry to solve problems in this field of research. 

The discovery, ca. 1968, by B. Rosenberg, that the cis isomer has anti-tumor activity stimulated the synthesis and screening of over 2000 different types of complexes with different amines and anionic ligands. Platinum compounds are among the most effective medications for the treatment of advanced cancer PtCl2(NH3)2 ( Cisplatin ) is mainly used for the treatment of testicular and ovarian cancer. One of its drawbacks are the severe toxic side-effects which may be related to the facile hydrolysis of Cl ligands under physiological conditions ... 

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