Medicated oils

Tam LS, Chan TYK, Leung WK, Critchley JAJH. Warfarin interactions with Chinese traditional medicines danshen and methyl salicylate medicated oil. 

Emulsions have been used for centuries for the oral administration of medical oils and vitamins and as dermatological vehicles. Recently, their application has been extended as drug carriers in the delivery and targeting of ophthalmic drags. An indomethacin emulsion has been reported to increase ocular bioavailability and efficacy compared to commercially available formulation in rabbits. 0.4% indomethacin emulsion showed 2.2 fold increase in the area under the anterior aqueous drag concentration/time curve compared to a 1% indomethacin suspension. The emulsion formulation also reduced ocular surface irritation caused by indomethacin Similar advantages have been shown for a pilocarpine emulsion which produced a prolonged therapeutic effect in comparison with pilocarpine hydrochloride eyedrops in man. It can be administered only twice a day, rather than four times daily for conventional formulation. 

Oils Any liquid that greases i.e., leaves, when dropped on a cloth, a stain which water does not wash out this stain makes paper translucent. If a solid substance exhibits similar properties, it is called a fat. Oils are called volatile or fixed, according to whether this stain disappears on warming or is permanent because of the nonvolatility of the oil. A few medicated oils, such as Phenolated Oil N.F. and Phosphorated Oil N.F., were briefly official. ... 

Chan TY. Ingestion of medicated oils by adults the risk of severe salicylate poisoning is related to the packaging of these products. Hum Exp Toxicol 2002 21(4) 171-4. 

Medicated oil- oil preparation obtained by steeping the medicinal herb in oil for several days or months. 

Products and Uses Various applications include as luminous paint, depilatories, acne medication, oil additive also as a preservative in paints and in skin products. 

Methyl salicylate, in the form of gels, oil, or ointment applied to the skin, has been found to increase the effects of warfarin. Bleeding and bruising and/or raised INRs have been seen with both high " and low doses of methyl salicylate. One report described the possible additive effects of methyl salicylate oil (Kwan Loong Medicated Oil) and a decoction of Danshen (the root of Salvia miltiorrhiza) on the response to warfarin (see also Coumarins and related drugs + Herbal medicines Danshen (Salvia miltiorrhizay, p.415). A raised prothrombin time has also been reported with topical trolamine salicylate. ... 

Case one was a 66-year-old man also taking digoxin and propanolol (Tam et al. 1995). Five days prior to admission due to melena (dark-colored feces) and chest pain, and 2 days prior to treatment, the man had self-treated with a topically applied medicated oil that contained 15% methyl salicylate. Methyl salicylate has been shown to augment the anticoagulant effect of warfarin (Chan 1995, 1998 Chow et al. 1989 Joss and LeBlond 2000 Yip et al. 1990). 

Tam, L.S., T.Y.K. Chan, W.K. Leung, and J. Critchley. 1995. Warfarin interactions with Chinese traditional medicines Danshen and methyl salicylate medicated oil. Intern. Med.. 25(3) 258. 

US Food and Drug Administration. FDA warning consumers advised not to use Arrow Brand Medicated Oil Embrocation, Aceite Medicinal La Flecha, or http //www.fda.gov/NewsEvents/Newsroom/ PressAimouncements/ucm213596.htm. 

Applications aircraft, automotive, bearings, bushings, connectors, electrical/ electronics, film, fuel lines, gears, medical, oil/gas, semiconductors, seals ... 

Applications - automotive, aircraft, coatings, composites, electronics, fiber, food, medical, oil gas, textiles ... 

Isopropyl alcohol is prepared from petroleum by hydration of propene With a boil mg point of 82°C isopropyl alcohol evaporates quickly from the skin producing a cool mg effect Often containing dissolved oils and fragrances it is the major component of rubbing alcohol Isopropyl alcohol possesses weak antibacterial properties and is used to maintain medical instruments m a sterile condition and to clean the skin before minor surgery... 

The principal uses of PCTFE plastics remain in the areas of aeronautical and space, electrical/electronics, cryogenic, chemical, and medical instmmentation industries. AppHcations include chemically resistant electrical insulation and components cryogenic seals, gaskets, valve seats (56,57) and liners instmment parts for medical and chemical equipment (58), and medical packaging fiber optic appHcations (see Fiber optics) seals for the petrochemical /oil industry and electrodes, sample containers, and column packing in analytical chemistry and equipment (59). 

In certain brilliantine compositions, vegetable and animal oils are used as substitutes for mineral oil. In these systems, because of their potential for rancidity, antioxidants must be included. Other alternatives to mineral oils that have found utiHty in brilliantines are the polyethylene glycols which come in a variety of solubiHties and spreading properties. Use of these materials offers the advantage of chemical stabiHty to rancidity. Other additives found in brilliantines to improve their aesthetics include colorants, fragrance, medicated additives, lanolin, and fatty acid esters. 

Propylene oxide is a useful chemical intermediate. Additionally, it has found use for etherification of wood (qv) to provide dimensional stabiUty (255,256), for purification of mixtures of organosiUcon compounds (257), for disinfection of cmde oil and petroleum products (258), for steriliza tion of medical equipment and disinfection of foods (259,260), and for stabilization of halogenated organics (261—263). 

The a—and P-aHoys are used where higher strengths are required, such as in shafts, oil and gas weUs, and medical implants. Again, Pd and Ru variations of the basic alloys are available where improved corrosion resistance is needed. Several of the Hsted P-aHoys were developed for implants. These alloys were designed to be free of aluminum and vanadium, which have created some concern related to potential toxicity when used in implants (50). 

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