Mazindol

Endomethylene-A -tetrahydro benzaldehyde Cyclothiazide Epibromohydrin Carteolol Epichlorohydrin Acebutolol Atenolol Befunolol Betaxolol HCI Bufetrol Bunitrolol Bupranolol Carazolol Carnitine Celiprolol Colestipol Cromolyn sodium I ndenolol Mazindol Mepindolol Metoprolol tartrate Nadolol Nifuratel Oxprenolol Penbutolol Practolol Propafenone HCI Propranolol HCI Viloxazine HCI Xanthinol niacinate Epinephrine... 

C14H13CIN2O 6038-49-9) see Mazindol 9b-(4-chlorophenyl)-l,2,3,9b-tetrahydro-l-[(4-metbylphe-nyl)sulfonyl]-5/7-imidazo[2,l-soindol-5-one (C23H19CIN2O3S 22590-16-5) see Mazindol... 

C7H7CIO2S 98-59-9) see Benproperine Brinzolamide Carzenide Cefoxitin Diazepam Flurotyl Fosinopril Gusperimus trihydrochloride Idarubicin Idoxuridine Indeloxacine Levocabastine Mazindol Medazepam Mibefradil hydrochloride Nemonapride Pioglitazone Prenalterol Ropinirole Tinidazole Tolterodine p-toluenesulfonamide... 

Amantidine, bromocriptine, mazindol, pergolide, cabergoline, L-dopa/carbidopa, pramipexole, ABT-431, catecholamine metabolism inhibitors (disulfiram, phenelzine, selegiline), amineptine Methylphenidate, /-amphetamine, tropanes, GBR-12909 (partial agonist that may also act as antagonist), modafinil, coca tea... 

Because chronic cocaine use appears to reduce the efficiency of central dopamine neurotransmission, a number of dopaminergic compounds, including amantadine, bromocriptine, mazindol, and methylphenidate, have been examined as treatments for cocaine abuse. It is thought that these relatively slow-onset dopaminergic agents, with low or relatively low abuse potential, would correct the dopamine dysregulation and alleviate withdrawal symptoms following chronic stimulant use. 

In contrast, following a treatment regimen of 20 mg/kg MDMA, there were no significant differences in the density of [3H]mazindol-labeled norepinephrine (NE) uptake sites (fmol/mg protein) in the frontal cerebral cortex between saline-treated (159 17) and MDMA-treated (152 5) animals. With respect to the dose of MDMA, serotonin levels appeared to be more readily decreased (45 percent reduction at 5 mg/kg), while comparable reductions in 5-HlAA levels and serotonin uptake sites were noted only at 10 or 20 mg/kg MDMA. This apparent discrepancy among the three serotonergic markers measured in the present study may relate to effects of lower doses of MDMA on synthetic enzyme activity (i.e., TPH), whereas the effects of higher doses of MDMA in reducing all three markers may relate in part to effects on TPH activity and in part to destruction of serotonin neurons as evidenced by decreases in serotonin uptake sites. 

Zimanyi, I., Lajitha, A., and Reith, M.E.A., Comparison of characteristics of dopamine uptake and mazindol binding in mouse striatum, Naunyn-Schmiedeberg s Arch. Pharmacol., 240, 626, 1989. 

Javitch, J.A., Blaustein, R.O., and Snyder, S.H., [3H]Mazindol binding associated with neuronal dopamine and norepinphrine uptake sites, Mol. Pharmacol., 26, 35, 1984. 

Madras, B.K. and Kaufman, M.J., Cocaine accumulates in dopamine-rich regions of primate brain after I.V. administration comparison with mazindol distribution, Synapse, 18, 261, 1994. 

Pogiin, S., Scheffel, U., and Kuhar, M.J., Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909, Eur. J. Pharmacol., 198, 203, 1991. 

Shankaran, M., Yamamoto, B.K., and Gudelsky, G.A., Mazindol attenuates the 3,4-methylene-dioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum, J. Neurochem. 72(6), 2516-2522, 1999. 

Barker, E. L., Perlman, M. A., Adkins, E. M Houlihan, W. J., Pristupa, Z. B Niznik, H. B and Blakely, R. D. (1998) High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J. Biol. Chem. 273, 19459-19468. 

Mazindol (Sanorex) (hydrochloride), 3 91, 92t Mazu, commercial defoamer, 8 24 It m-base dyes, 9 474 MBS polymers, 16 290 McBee-Hass chlorination technique, 16 322 McCabe—Thiele diagram... 

Qosely related chemically to amphetamine are the so-called appetite suppressants or anorexiants, such as fenfluramine, mazindole, and sibutra-mine. These may also cause dependence and their therapeutic value and safety are questionable. 

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