Target dose

Review doses of medications for appropriateness. Aspirin dose should be less than 160 mg/day. Titration toward target doses of ACE inhibitors and P-blockers should be in progress. 

Amitriptyline (Elavil) 10-25 mg at bedtime with weekly increments to a target dose of 25-150 mg of amitriptyline or an equivalent dose of another TCA ... 

Second-Generation Antipsychotic Usual Target Dose (mg/day) Maximal Dose Likely to Be Beneficial (mg/day) Available Dosage Forms... 

Buspirone should be initiated at a dose of 7.5 mg twice daily and titrated in 5 mg/day increments (every 2-3 days) to a usual target dose of 20 to 30 mg/day.41 The maximum daily dose is considered to be 60 mg/day. 

Captopril 6.25 to 12.5 mg initially target dose 50 mgtwoorthree times daily. 

Enalapril 2.5 to 5 mg initially target dose 10 mg twice daily. 

Ramipril 1.25 to 2.5 mg initially target dose 5 mg twice daily or 10 mg once daily. 

Trandolapril 1 mg initially target dose 4 mg once daily. 

Target doses associated with survival benefits in clinical trials. 

Because of their negative inotropic effects, /J-blockers should be started in very low doses with slow upward dose titration to avoid symptomatic worsening or acute decompensation. Patients should be titrated to target doses when possible to provide maximal survival benefits. However, even lower doses have benefits over placebo, so any dose is likely to provide some benefit. 

Carvedilol, 3.125 mg twice daily initially target dose, 25 mg twice daily (the target dose for patients weighing more than 85 kg is 50 mg twice daily). Carvedilol CR should be considered in patients with difficulty maintaining adherence to the immediate-release formulation. 

Metoprolol succinate CR/XL, 12.5 to 25 mg once daily initially target dose, 200 mg once daily. 

Doses should be doubled no more often than every 2 weeks, as tolerated, until the target dose or the maximally tolerated dose is reached. Patients... 

Valsartan, 20 to 40 mg twice daily initially target dose, 160 mg twice daily. 

Initial doses should be low (spironolactone 12.5 mg/day eplerenone 25 mg/day), especially in the elderly and those with diabetes or creatinine clearance <50 mL/min. A spironolactone dose of 25 mg/day was used in one major clinical trial. The eplerenone dose should be titrated to the target dose of 50 mg once daily, preferably within 4 weeks as tolerated by the patient. 

In adults, the starting dose of oxcarbazepine as monotherapy is 300 mg once or twice daily. This can be increased by 600 mg/day each week to a maximum dose of 2,400 mg/day. This is titrated to the target dose over 2 weeks. See manufacturer s recommendations for dosing by weight. 

The role of theophylline in COPD is as maintenance therapy in non-acutely ill patients. Therapy can be initiated at 200 mg twice daily and titrated upward every 3 to 5 days to the target dose most patients require daily doses of400 to 900 mg. 

The final tally for phase one two men were incapacitated and two were moderately impaired although still partially functional. Two out of four was the statistically optimal fraction. We had precisely bracketed the target dose. The generators had indeed floated the equivalent of slightly more than two aspirin to half the oup, and shghtly less Jan ... 

On Saturday, I ruminated some more about the feasibility of achieving satisfactory results at 1,000 yards, where it would theoretically take four times as much BZ to reach the same target dose. However, if the volunteers increased their breathing volume sufficiently, we could cut the exposure time by half, maybe even more. 

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