Matrix tablets granulation

Sheskey P, Sackett G, Maher L, Lentz K, Tolle S, Polli J. Roll Compaction Granulation of a Controlled-Release Matrix Tablet Formulation Containing HPMC, Pharmaceutical Technology Tableting and Granulation Year book. Advanstar Communications, Pittsfield Mass. 1999 6-21. 

Sheskey P, Pacholke K, Sackett G, Maher L, Polli J. Roll compaction granulation of a controlled-release matrix tablet formulation containing HPMC. Pharm Technol 2000 24(ll) 30-52. 

Dahl TC, Bormeth AP. Naproxen controlled release matrix tablets fluid-bed granulation feasibility. Drug Dev Ind Pharm 1990 16(4) 581-590. 

Theophylline tablets made by both direct compression and wet granulation have been assessed. There is almost no difference between direct compression and wet granulation methods (see Figures 12-14) under the following conditions appropriate formulation (sufficient level of HPMC in the tablet) and precise control of the wet granulation process. Direct compression using Metolose SR is recognized as a suitable process for matrix tablets. 

Sheskey, P. J., and Williams, D. M. (1996), Comparison of low-shear and high-shear wet granulation techniques and the influence of percent water addition in the preparation of a controlled-release matrix tablet containing HPMC and a high-dose, highly water-soluble drug, Pharm. Technol., 20, 80, 82, 84, 86, 88, 90, 92. 

Wax matrix tablets are prepared either by compression of the wax granules or beads described in the previous section, or, with the higher melting waxes available in powder form, by direct compression of powder blends. When compared with polymeric matrix materials, the amount of waxes within the tablet is limited because of fusion and sticking to the punches at higher wax concentrations. This problem could possibly be overcome by compression at lower temperatures. 

Many solid-dosage forms of potassium chloride exist including tablets prepared by direct compression and granulation effervescent tablets coated, sustained-release tablets " sustained-release wax matrix tablets micro-capsules pellets and osmotic pump formulations. ... 

Kawashima Y Takeuchi H, Hi no T, Niwa T, Ohya M. Preparation of prolonged-release matrix tablet of acetaminophen with pulverized low-substituted hydroxypropylcellulose via wet granulation. Int J Pharm 1993 99 229-38. 

Hydrophilic matrix tablets are manufactured using traditional tablet manufacturing methods of direct compression (DC), wet granulation or dry granulation (roller compaction or slugging) depending on formulation properties or on manufacturer s... 

Tanaka N, Imai K, Okimoto K, Ueda S, Tokunaga Y, Ibuki R, HigaM K, Kimura T (2006) Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of ndvadipine (II) in vivo evaluation. J Control Release 112 51-56... 

Xu, G, Sunada H, Zhang R. Indomethacin controlled release matrix tablet prepared by wet granulation procedure. Chem Pharm Bull 1997 45(1) 214—216. 

Bouckaert S, Massart DL, Massart B, Remon JP. Optimization of a granulation procedure for a hydrophilic matrix tablet using experimental design. Drug Dev Ind Pharm... 

A. Khanum, D.S. Gayathri, Comparative evaluation of matrix tablet of diclofenac sodium employing wet granulation and direct compression method using blend of polymers. Res J Pharm and Technol, 1 (3), 265-269,2008. 

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