Oral drug delivery matrix systems

Extended-Release Oral Drug Delivery Technologies Monolithic Matrix Systems... 

A prerequisite of oral drug delivery by SLN is, however, a sufficient stability of the carrier system in the gastrointestinal fluids itself. Zimmermann and Muller studied different SLN formulations with respect to their GIT stability. No general conclusion could be drawn and aggregation and instability seems to be dependent on the lipid matrix as well as on the stabilizer system. A minimum of 8-9 mV zeta potential together with steric stabilization was found to be the prerequisites for SLN stability in the GIT.205... 

S.B. Tiwari, and A.R. Siahboomi, Extended-release oral drug delivery technologies Monolithic matrix systems, in KK. Jain, ed.. Drug Delivery Systems, Humana Press, Totowa, NJ, 217-243, 2004. 

Nokhodchi, S. Raja, P. Patel and K. Asare-Addo, The role of oral controlled release matrix tablets in drug delivery systems, BioImpacts, 2 (4) 175-187, 2012. 

Oral drug delivery systems provide a safe route for the drugs to be directly released into the gastrointestinal tract. Nano chitosan blended alginate matrix (CBAM) by grafting with poly methacrylic acid (PMAA) recently being developed for the oral drug delivery. Such a system showed... 

Hydrophobic polymers are often used to deliver biomacromolecules regardless of the route of administration. The rapid transit time of approximately 8 hours limits the time of a device in the gastrointestinal (GI) system, consequently the mechanisms possible for oral drug release are limited. The predominant method of release from hydrophobic polymers has been degradation, or biodegradation, of a polymeric matrix by hydrolysis (Figure 11.1). In fact, all of the hydrophobic polymers described in this chapter for use as oral protein or peptide delivery are hydrolytically unstable. 

Transbuccal drug delivery systems are a new technology and spinoff of transdermal/topical drug delivery systems. Similar to monolithic adhesive matrix—type skin patches, transbuccal systems are designed to adhere to mucosal tissue in the oral cavity. A number of compounds are being evaluated in clinical studies.88... 

Varma MVS, Kaushal AM, Garg A, Garg S. Factor affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems. Am J Drug Deliv 2004 2(1 ) 43-67. 

Khan GM. Controlled release oral dosage forms some recent advances in matrix type drug delivery systems. Sciences 2001 ... 

Drug delivery systems of once-daily products (Concerta, Metadate CD, Ritalin LA, Adderall XR) provide 8 to 12 hours of symptom control. Concerta uses an oral osmotic (OROS) controlled-release delivery system, while other preparations use combinations of immediate-release or extended-release beads containing drug. Concerta is a nondeformable tablet and it should not be given to children with gastrointestinal narrowing due to the risk of obstruction. Older wax-matrix sustained-release products (e.g., Ritalin SR)... 

In several investigations the feasibility of development of a sustained-release form for diclofenac sodium was studied. Matrix-type formulation was designed, which appears to be a very attractive approach from process development and scale up points of view. HPMC is the most important hydrophilic polymer used for the preparation of oral controlled-release drug-delivery systems. - One of the most important characteristics of HPMC is the high swellability, which has a considerable effect on the release kinetics of the incorporated drug. 

---