Matrix-assisted laser desorption design

Loboda A.V., Krutchinsky A.N., Bromisrski M., Ens W., and Standing K.G. (2000), A tandem quadrupole/time of flight mass spectrometer with a matrix-assisted laser desorption/ionization source design and performance, Rapid Commun. Mass Spectrom. 14, 1047-1057. 

API offers unique opportunities for the implementation of new sources or to develop new applications. Atmospheric pressure matrix assisted laser desorption (AP-MALDI) [21] can be mounted on instruments such as ion traps which were originally designed only for electrospray and LC-MS. New API desorption techniques such as desorption electrospray (DESI) [22] or direct analysis in real time (DART) [23] have been described and offer unique opportunities for the analysis of surfaces or of solid samples. 

Kussmann M, Nordhoff E, Rahbek-Nielsen H, Haebel S, Rossel-Larsen M, Jakobsen L, Gobom J, Mirgorodskaya E, Kroll-Kristensen A, Palm L, Roepstorff P (1997) Matrix-assisted laser desorption/ionization mass spectrometry sample preparation techniques designed for various peptides and protein analytes. J Mass Spectrom 32 593-601... 

Matrix assisted laser desorption ionization - time of flight mass spectrometry MDL Drug Data Report Molecular Design Limited Molecular orbital Mass spectrometry Molecular weight National Cancer Institute Neurokinin... 

Tseng, K., Liu, J., Lebrilla, C. B., Collins, S. D. and Smith, R. L. Fabrication and design of open microchannels for capillary electrophoresis separations and matrix-assisted laser/desorption mass spectroscopy analysis. Proc SPIE Int Soc Opt Eng, 3606, 137, 1999. 

Kussmann, M., Nordhoff, E., Rahbek-Nielsen, H., Haebel, S., Rossel-Larsen, M., Jakobsen, L., Gobom, J., Mirgorodskaya, E., Kroll-Kristensen, A., Pahn, L., and Roepstorff, R, Matrix-assisted laser desorption/ionization mass spectrometry sample preparation techniques designed for various peptide and protein analytes, Journal of Mass Spectrometry, 32, 593-601, 1997. 

Loboda, A.V. Krutchinsky, A.N. Bromirski, M. Ens, W. Standing, K.G. A tandem qua-drupole/time-of-liightmass spectrometer with a matrix-assisted laser desorption/ionization source Design and performance. Rapid Commun. Mass Spectwm. 2000,14,1047-1057. 

J.L, and Costello, C.E. (2004) A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces. J. 

Though SFC interfacing in an online fashion with an matrix assisted laser desorption ionization (MALDI) source has not yet been reported, the analysis of fractions from an SFC separation has been facilitated by the recent design of an online sample desorption device for MALDI.In this device, the end of the column is connected to an integral restrictor positioned over a spot of C18 sorbent saturated with an appropriate sample matrix such as a-cyano-4-hydroxycinnamic acid. The technique was applied to the separation of a silicone oil. MALDI-MS elucidated the polymer distributions corresponding to fractions deposited over a range of SFC retention times. 

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