Mass spectrometry development

G. Holland and S.D. Tanner (eds), Plasma Source Mass Spectrometry. Developments and Applications, The Royal Society of Chemistry, Cambridge (1997). 

Crawford, L. R., Morrison, J. D. Anal. Chem. 43, 1971, 1790-1795. Computer methods in analytical mass spectrometry. Development of programs for analysis of low resolution mass spectra. 

Instrumental developments facilitate the miniaturization opportunity. Advances in chromatography led to the use of capillary HPLC techniques (Liu et al., 1993 Kassel et al., 1994 Arnott et al., 1995) for the powerful separations of increasingly smaller samples. For mass spectrometry, developments with the LC/MS interface that resulted in increased ion transmission and ion sampling helped to... 

Tanner, S. D. In Plasma Source Mass Spectrometry Developments and Applications Holland, G. R, Tanner, S. D., Eds. Royal Society of Chemistry Cambridge, 1997, 13-27. 

A. G. Cox, C. W. McLeod, M. Nishikawa, D. Wiederin, in G. Holland, S. D. Tanner (Eds), Plasma Source Mass Spectrometry — Developments and Applications, The Royal Society of Chemistry, Cambridge, Special Publication, 202 (1997), 145-151. 

D. W. Roppenall, G. C. Eiden, C. J. Barinaga, Collision and reaction cells in atomic mass spectrometry development status and applications, J. Anal. Atom. Spectrom., 19 (2004), 561-570. 

Plasma mass spectrometry developed on the basis of the experience gathered with the extraction of ions from flames, as was done for diagnostic purposes in the mid-1960s [493]. 

Holland G and Tanner SD, eds. (1997) Plasma source mass spectrometry. Developments and applications. Spec Publ R Soc Chem (202) 1-329. 

The cathode-ray tubes were also found to eject positive ions in the opposite direction from the electrons. These canal rays were comprised of much more massive particles. J.J. Thomson (1906 Nobel Prize in Physics) used a magnetic field to bend the paths of these ions and record their collisions on film. He discovered that pure neon gas produced two masses, 20 and 22, due to isotopes. The term was coined by Frederick Soddy (1921 Nobel Prize in Chemistry) during his studies of radioactive elements having the same chemical but different radioactive properties. The separation of positive ions using a magnetic field followed by recording them on a photographic plate is the basis of mass spectrometry, developed by Francis W. Aston (1922 Nobel Prize in Chemistry). ... 

Starting in the 1960s, a technique called ion cyclotron resonance (ICR) mass spectrometry, developed hy John Brauman (1937- ) at Stanford University, facilitated measurement of the products formed from gas-phase reactions between molecules and ions. Jesse L. Beauehamp (1942- ), at Caltech, was an early investigator of this new gas-phase chemistry. In contrast to the solution-phase chemistry, in the gas phase toluene is a stronger acid than methanol ... 

Elwaer A.E., McLeod C.W, Thompson K.C. and Wiederin D. 1996. Plasma Source Mass Spectrometry Developments and Applications, Royal Society of Chemistry, London, p. 124. Elwaer A.R. 1999 PhD Thesis, University of Sheffield, UK, Chemistry Department, Elwaer A.R., McLeod C.W. and Thompson K.C. 2000. Anal. Chem., 72, 5725-5730. 

Cliff, B., Lockyer, N., Jungnickel, H., Stephens, G, Vickerman, J.C. (2003) Probing cell chemistry with time-of-fiight secondary ion mass spectrometry development and exploitation of instrumentation for stndies of frozen-hydrated biological material. Rapid Commun. Mass Spectrom., 17,2163-2167. 

Lorber, A., Halicz, K., and Karpas, Z. (1997). Uranium in urine and serum of normal populations A FI AS-ICPMS study. In Tanner, H. A. (ed.). Plasma Source Mass Spectrometry Developments and Applications. London, U.K. Royal Society of Chemistry. 

Plasma mass spectrometry developed on the basis of the experience gathered from the extraction of ions from flames, as performed for diagnostic purposes in the mid-1960s [296]. In 1980 Gray, Hour, and coworkers [297] first showed the analytical possibilities of ICP-MS. The method has the same ease of sample introduction... 

Rompp A, Taban IM, Mihalca R, Duursma MC, Mize TH, McDonnel LA, Heeren RM. Examples of Fourier transform ion cyclotron resonance mass spectrometry developments from ion physics to remote access biochemical mass spectrometry. Eur J Mass Spectrom. 2005 11 443-56. 

Han, X., Yang, K. and Gross, R.W. (2008) Microfluidics-based electrospray ionization enhances intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry Development of an automated high throughput platform for shotgun lipidomics. Rapid Commun. Mass Spectrom. 22, 2115-2124. 

The technologies described here have had major effects in developing new paradigms in biology. The mass spectrometry developments, in conjunction with... 

P. Tnrner, T. Merren, J. Speakman, and C. Haines, Plasma Source Mass Spectrometry Developments and Applications, ISBN 0-85404-727-1, 28-34, 1996. 

Slow dissociation rates (10 -10 s ) have been measured in Dunbar s laboratory by time-resolved photodissociation, which consists of trapping ions in an ICR cell during a variable delay time after a phot-odissociating photon pulse. The technique called time-resolved photoionization mass spectrometry , developed by Lifshitz, consists of trapping photoions in a cylindrical trap at very low pressure to avoid bimolecular collisions, and then ejecting them into a mass filter after a variable delay covering the microsecond to millisecond range. When the dissociation rate constant becomes lower than ca. 10 s competition with infrared fluorescence takes place and limits the lifetime of the decomposition process. This has to be taken into account to extract the dissociation rate constant from the experimental data. 

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