Mass spectrometry advances

Thevis M, Vollmer DA (2012) Recent instrumental progress in mass spectrometry advancing resolution, accuracy and speed of drug detection 4 242-245... 

Naylor S, Johnson KL, Williamson BL, Klarskov K, and Gleich GJ (1999) Structural characterization of contaminants in commercial preparations of melatonin by on-line HPLG-electrospray ionization-tandem mass spectrometry. Advances in Experimental Medicine and Biology 467 769-777. 

Schnitzer M and Schulten HR (1995) Analysis of organic matter in soil extracts and whole soils hy pyrolysis mass spectrometry. Advances in Agronomy 55 167-217. 

Fifield, L.K. (2004) Applications of accelerator mass spectrometry advances and innovation. Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms, 223-224, AOl-All. 

Mass Spectrometry. Advances in soft ionization techniques and developments in high resolution mass spectrometers has led to the possibility of determining intact molecular ions up to 1 x 10 Da and the measurement of the entire MWD (235,236). The application of mass spectrometry techniques to characterize polymer molecular weight distribution has evaluated (237-243). The MWD of polystyrene SRM 1487 and a narrow MND polymethylmethacrylate (MW 6300) determined by MALDITOF mass spectrometry have been compared with results from the ultracentrifuge and GPC (244). 

Green FM, Salter TL, Stokes R et al. Ambient mass spectrometry advances and applications in forensics. Surf Interface Anal. 2009 42 347-57. 

Craig, R.D., G.A. Errock and J.D. Waldron, 1959, Determination of impurities in solids by spark source mass spectrometry. Advanc. Mass Spectr. 1, 136. 

Gardella, J.A., Graham, S.W., Hercules, D.M., in E.D. Carver (Ed.), Structural Characterization of Polymeric Materials by Laser Desorption Mass Spectrometry. Advances in Chemistry Series 303, American Chemical Society, Washington DC, 1983, p. 635. 

Interest in this method has decreased since advances made in gas chromatography using high-resolution capillary columns (see article 3.3.3.) now enable complete identification by individual chemical component with equipment less expensive than mass spectrometry. 

Vartanian V H, Anderson J S and Laude D A 1995 Advances in trapped ion cells for Fourier transform ion cyclotron resonance mass spectrometry Mass Spec. Rev. 41 1-19... 

However, interpretation of, or even obtaining, the mass spectrum of a peptide can be difficult, and many techniques have been introduced to overcome such difficulties. These techniques include modifying the side chains in the peptide and protecting the N- and C-terminals by special groups. Despite many advances made by these approaches, it is not always easy to read the sequence from the mass spectrum because some amide bond cleavages are less easy than others and give little information. To overcome this problem, tandem mass spectrometry has been applied to this dry approach to peptide sequencing with considerable success. Further, electrospray ionization has been used to determine the molecular masses of proteins and peptides with unprecedented accuracy. 

Wangzhao, Z., Advanced Inductively Coupled Plasma Mass Spectrometry Analysis of Rare Elements, Balkema Publishers, 1999. 

Tandem mass spectrometry or ms/ms was first introduced in the 1970s and gained rapid acceptance in the analytical community. The technique has been used for stmcture elucidation of unknowns (26) and has the abiUty to provide sensitive and selective analysis of complex mixtures with minimal sample clean-up (27). Developments in the mid-1980s advancing the popularity of ms/ms included the availabiUty of powerhil data systems capable of controlling the ms/ms experiment and the viabiUty of soft ionisation techniques which essentially yield only molecular ion species. 

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... 

Snne Bergstrom and his colleagues described the first structural determinations of prostaglandins in the late 1950s. In the early 1960s, dramatic advances in laboratory techniques such as NMR spectroscopy and mass spectrometry made further characterization possible. 

Beckey, H. D., Mass Spectrometry, A NATO Advanced Study Institute... 

Structure determination of luciferin. Once a luciferin is obtained in a sufficient purity, the determination of luciferin structure should be attempted most of the important properties of luciferin are usually already obtained during the course of purification as a necessity. The structural study is considerably more straightforward than the extraction and purification, due to the availability of advanced methods, such as high-resolution mass spectrometry and various NMR techniques. If help or collaboration is needed in structure determination, the attractiveness of a luciferin will make it easy to find a good collaborator. However, the purified luciferin is usually an extremely precious material considering the effort spent in preparing it. To avoid accidental loss of the purified material, the chosen collaborator must have solid knowledge and experience in structure determination a criterion to be considered is that the person has successfully done the structure determination of at least one new natural product. 

Tao WA, Aebersold R (2003) Advances in quantitative proteomics via stable isotope tagging and mass spectrometry. Curr Opin Biotechnol 14 110-118... 

Ed, Advances in Mass Spectrometry , Pergamon Press, Oxford (1963), pi 10) R.M. Silverstein G.C. Bassler, Spectrometric Identification of Organic Compounds , J. Wiley Sons, NY (1963)... 

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