Marek’s disease virus

Parcells MS. Marek s disease virus (MDV) encodes an interleukin-8 homolog (vIL-8) characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV. J Virol 2001 75(11) 5159 73-... 

Other herpesviruses of animals. Herpesviruses that have been found in squirrel and spider monkeys have been shown to have oncogenic potential. Other oncogenic herpesviruses include Marek s disease virus of chickens (206 p.209), the Lucke virus of frogs, and Herpesvirus sylvilagus of the cottontail rabbit. 

Sharma, J.M., R.L. Witter, B.R. Burmester, and J.C. Landon. 1973. Public health implications of Marek s disease virus and herpesvirus of turkeys. Studies on human and subhuman primates. J. Nat. Cancer Inst. 51 1123-1127. 

Cross contamination of vaccines with other pathogens has also resulted in mortality and morbidity in animals. These incidents have included pseudorabies virus contaminated with pestivirus, Marek s disease virus contaminated with reticuloendotheliosis virus, contamination of cell lines and vaccines with bovine diarrhoea virus, bluetongue in dogs arising from contaminated live canine vaccine and clostridial disease in ruminants of 202 523 animals in affected herds, 41 767 were infected with Clostridium sordellii and 22 189 died, possibly as a result of a failure in a sterility test for detecting contaminants in a clostridial vaccine. 

In the rat, AgB-associated differences in response to a number of synthetic polypeptide and foreign protein antigens have been described . In the chicken, the B-locus, or a linked genetic factor, has been found to control resistance to Marek s disease (an avian leukosis virus-induced lymphoma), and also to autoimmune thyroiditis . Differences in response to the synthetic polypeptide (T,G)-A-L have also been observed . An extremely interesting observation in the chicken indicates a requirement for shared products of the same MHC haplotype in order for effective T cell—B cell cooperation to take place, as in the mouse. 

A. Fadly, R. Silva, H. Hunt, A. Pandiri and C. Davis, Isolation and characterization of an adventitious avian leucosis virus isolated from commercial Marek s disease vaccines. Avian Dis., 2006, 50, 380-385. 

G. 2j2cv2X2l and S. Cheng, Detection and characterization of avian leucosis virus in Marek s disease vaccine. Avian Dis, 2006, 50, 209-215. 

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