Manufacturing problems

Mousses pose Httle manufacturing problem, but because they are aerosolized they must be filled with special equipment. The pressure fill technique requites the container to be filled with mousse concentrate, then a valve is crimped on and a vacuum of approximately 2.4 kPa (18 mm Hg) is pulled. The propellants are added through the valve. Another technique, the under-the-cup method, fills the container under pressure with propellant and crimps the valve, all in one step. 

The next step is to define the intermediate event, tire failure. There are two events which could contribute a worn tire resulting from much usage or a tire that is defective owing to a manufacturing problem. These are both basic events because additional information is needed for any further definition. 

Vane thickness. Because of manufacturing problems and physical necessity, impeller vanes are thick. When fluid exits the impeller, the vanes no longer contain the flow, and the velocity is immediately slowed. Because it is the meridional velocity that decreases, both the relative and absolute velocities decrease, changing the exit angle of the fluid. 

During this period, the work schedule should be monitored to highlight any possible delays. Late shipments may be avoided if any materials, subvendor shipments, or manufacturing problems can be discovered early and if both parties work together to solve them. 

The report includes an evaluation of snubber performance operational, installation-related, and manufacturing problems are identified. General failure data with failure modes and respective frequencies is provided. 

In another plant, the industrial laboratory was installed close to the processing area down a short flight of stairs. Before this location was chosen, possible hazards and environmental effects were studied. Here it took little over one minute to bring samples to the laboratory or for laboratory personnel to be on hand to investigate manufacturing problems. 

Selection of the most suitable chemical form of the active principle for a tablet, while not strictly within our terms of reference here, must be considered. For example, some chloramphenicol esters produce little clinical response [13], There is also a significant difference in the bioavailability of anhydrous and hydrated forms of ampicillin [14], Furthermore, different polymorphic forms, and even crystal habits, may have a pronounced influence on the bioavailability of some drugs due to the different dissolution rates they exhibit. Such changes can also give rise to manufacturing problems. Polymorphism is, of course, not restricted to active ingredients, as shown, for example, in an evaluation of the tableting characteristics of five forms or sorbitol [15]. 

Manufacturer Bayer Corporation, Pharmaceutical Division, Elkhart, IN (supply may be limited due to manufacturing problems). 

Potentially result in shorter and fewer FDA inspections by lowering the risk of manufacturing problems... 

Hybrid bearings using Si3N4 ceramic balls with M-50 or other tool steel rings enable operation up to 300°C while avoiding the difficult manufacturing problems with ceramic rings (45). 

Another reason for the preference of up-numbering is actually due to a manufacturing problem. Tolerances in silicon etching are absolute tolerances which means that with decreasing size of the channels the geometric errors increase. This influence is balanced if a large number of channels are combined. 

Knowledge of the coordination polymerisation of olefins would not be complete without consideration of the types of process used in industry for polyolefin manufacture. Problems encountered in production influence developments in the area of catalysis in olefin polymerisation, an improvement in a catalyst being defined as leading to a reduction in the cost of making the polymer or giving better product properties. Therefore, the principal types of polyolefin production involving coordination catalysts of various types are dealt with briefly. Since modern polyolefin production processes offer a versatile range of polymers, the main commercially available olefin polymerisation products and their typical uses are also considered. 

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