Mammalian reproduction

Two-generation mammalian reproductive toxicity study or a less comprehensive test. 

Estes R.D. (1972). The role of the vomeronasal organ in mammalian reproduction. Mammalia 36, 315-341. 

Clagett-Dame M and DeLuca HF. 2002. The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22 347—381. 

Lactation is a basic period in mammalian reproduction, and the breast, its function, and pathology have a very important place in medicine and society. In developed countries breast cancer is the most important issue, far more important than nonlactational galactorrhea it is frequently related to infertility or unsuccessful breastfeeding and is a major health concern among women. 

Parkes, A.S. and Bruce, H.M. (1961) Olfactory stimuli in mammalian reproduction. Science. 134, 1049-1054. 

The term reproductive toxicity is used to describe the adverse effects induced by a substance on any aspect of mammalian reproduction and covers all phases of the reproductive cycle, including impairment of male or female reproductive function or capacity and the induction of nonheritable adverse effects in the progeny such as death, growth retardation, structural and functional effects (EC 2003). 

The assessment of a new pharmaceutical product for effects on reproduction must take into accoimt that mammalian reproduction is a complex, cyclical process involving a number of stages, each complicated in themselves. The stages include... 

Section 1 includes an introduction and a statement as to the aim of the recommended animal studies. The aim of the recommended studies is to reveal any effect (to the extent of the measurements/ parameters collected) of the active substance(s) on mammalian reproduction. As such, the studies are designed to incorporate exposure of mature adults and all stages of development from conception to sexual maturity. For convenience, the reproductive life cycle is divided into six periods (A through F) so that the periods assessed by each study criteria can be easily envisioned. The six periods are essentially as follows ... 

Organization for Economic Cooperation and Development (OECD) (2007) Draft guidance document on mammalian reproductive toxicity testing and assessment. OECD Environment, Health and Safety Publications, Series on... 

The gorgonian coral Plexaura homomalla is a source of prostaglandin A2. This compound can be converted to medically useful prostaglandins that regulate mammalian reproduction, blood pressure, and digestion. 

Reproduction toxicity, recently also called developmental toxicity, is a special part of toxicology which comprises any effect of chemicals and active substances on mammalian reproduction. The investigations and the interpretation of the results should be... 

Reproductive toxicology studies are conducted to reveal the effect of the drug candidate on mammalian reproduction and whether potential reproductive risks may exist for humans. These reproductive studies commonly use pregnant rats and rabbits as the test species. To ensure that the dams and the fetuses are appropriately exposed to the drug candidate and metabolites (11), the dams can be dosed with radiolabeled compound, and the amount of radioactivity that crosses the placenta and into the fetuses at various times after dosing can be... 

F. H. Bronson, Pheromonal Influences on Mammalian Reproduction. In Perspectives in Reproductive and Sexual Behaviour, M. Diamond, Ed. Indiana Press Bloomington, IN, 1968 pp 341-361. 

J. G. Vandenbergh, Pheromones and Mammalian Reproduction. In Knobil and Neill s Physiology of Reproduction, 3rd ed. ... 

Golbus MS (1981) Chromosome aberrations and mammalian reproduction. In Mastoianni L and Biggers JD (eds.) Fertilization and Embryonic Development In Vitro, pp. 257-272. New York Plenum. 

Prostaglandins play important roles in each step of mammalian reproduction. These prostaglandins appear to be COX-2 derived, as... 

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