Mammalian carcinomas

Daunomycin Soft-tissue sarcomas, Mammalian carcinoma, Hepatoma... 

Bailly, M. Yan, L. Whitesides, G. M. Condeelis, J. S. Segall, J. E., Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells, Exp. Cell Res. 1998, 241, 285-299... 

Montforts et further explored this approach by attaching hydrophilic carbohydrate structural units to certain chlorins (e.g., 406). Such conjugation increased the water solubility of the parent chlorins 407 and 408. By introducing an estradiol with a diethyl spacer, the chlorin-estrogen conjugate was then prepared in the hope that it would bind to an estrogen receptor which could induce selective destruction of mammalian carcinoma (Scheme 82). 

Persistent activation of PPARa can induce the development of hepatocellular carcinoma in susceptible rodent species by a nongenotoxic mechanism, i.e., one that does not involve direct DNA damage by peroxisome proliferator chemicals or their metabolites. This hepatocarcinogenic response is abolished in mice deficient in PPARa, underscoring the central role of PPARa, as opposed to that of two other mammalian PPAR forms (PPARy and PPAR5), in peroxisome proliferator chemical-induced hepatocarcinogenesis. Other toxic responses, such as kidney and testicular toxicities caused by exposure to certain phthalate... 

Nickel water-soluble salts were also reported to induce chromosome aberrations in CHO cells [444, 445] and in mouse mammary carcinoma cells [260, 446], Changes in growth control and chromosome aberrations in human bronchial cells were demonstrated in vitro after exposure to nickel sulphate the changes were insufficient to cause the cells to be tumourigenic [447], Nickel chloride was unable to produce chromosome aberrations in vivo in mammalian male germ cells [448],... 

Everolimus (40 Afinitor Novartis, 2009), a rapamycin analog, is the 42-0-(2-hydroxyethyl) derivative of sirolimus (34), and is marketed as an immunosuppressant by Novartis under the tradename Afinitor for use in advanced renal cell carcinoma.In March 2009, the FDA approved everolimus (40) for use against advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib. The drug works similarly to sirolimus as an inhibitor of mTOR (mammalian target of rapamycin), a serine-threonine kinase, downstream of the PI3K/AKT pathway. Everolimus (40) binds to an intracellular protein, EKBP-12, resulting in an inhibitory... 

There has also been much discussion of the interpretation of the finding of hepatocellular carcinomas and adenomas in mice in the NTP (1987) study. There was a higher than usual rate of these tumors in control female mice. Because 1,4-dichlorobenzene has not been demonstrated to be mutagenic in any of the microbial or mammalian systems tested, NTP (1987) has suggested that it may act as a tumor promoter by inducing DNA replication for tissue repair processes. As discussed previously, oral administration of... 

It has also been demonstrated that the staining of p53 in mammalian ductal carcinoma decreased after slides were stored for 2 months at room temperature, but the antigen loss... 

ProstaScint Capromab Pendetide Cytogen Corp 10/1996 Labeled with Indium 111 for imaging of prostatic carcinoma Mammalian cells... 

---