Malignant ependymoma

Ependymoma/ Structures of ependymoma or malignant CFAP (S) cytokeratin Cerebellum ... 

Anaplastic ependymomas are ependymomas with malignant features, including conspicuous mitotic activity, nuclear and cellular pleomorphism, multinucleated and... 

Histopathologic features of malignancy do not accurately predict poor survival. This problem may eventually be solved by IHC. The combination of increased vimentin expression and decreased GFAP expression may predict poor survival in infratentorial anaplastic ependymomas. Anaplastic ependymomas are more likely to overexpress p53 or EGER protein than low-grade ependymomas. ... 

The features of anaplastic transformation in oligodendroglioma are similar to those in anaplastic ependymoma (Fig. 20.27). Fiowever, limited amounts of vascular proliferation are frequently present in oligodendroglioma, and in isolation, they cannot be considered evidence of malignant transformation (see Table 20.6). Vascular proliferation is highlighted by vimentin and CD31 stains. 

Malignant mixed oligo-astrocytomas and ependymomas had a 2 year survival of 37% and 75% respectively. 

T-cell lymphoma, ALCL, AML, GIST, breast metaplastic carcinoma, ovarian sex cord stromal tumors, synovial sarcoma, Merkel cell carcinoma, endocrine and neuroendocrine tumors, desmoplastic small round cell tumor, melanoma, nephroblastoma, ependymoma, mesenchymal chondrosarcoma, extrarenal malignant rhabdoid tumor, rhabdomyosarcoma, meningeal... 

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