Anaplastic ependymoma

Anaplastic ependymoma Preceding features with mitoses necrosis GFAP (S) S-100 Cerebrum cerebellum... 

Anaplastic ependymomas are ependymomas with malignant features, including conspicuous mitotic activity, nuclear and cellular pleomorphism, multinucleated and... 

Histopathologic features of malignancy do not accurately predict poor survival. This problem may eventually be solved by IHC. The combination of increased vimentin expression and decreased GFAP expression may predict poor survival in infratentorial anaplastic ependymomas. Anaplastic ependymomas are more likely to overexpress p53 or EGER protein than low-grade ependymomas. ... 

The features of anaplastic transformation in oligodendroglioma are similar to those in anaplastic ependymoma (Fig. 20.27). Fiowever, limited amounts of vascular proliferation are frequently present in oligodendroglioma, and in isolation, they cannot be considered evidence of malignant transformation (see Table 20.6). Vascular proliferation is highlighted by vimentin and CD31 stains. 

Notch. Anaplastic astrocytoma, ependymoma, medulloblastoma, Jag-activated Notch. Click Feletti A et al Brain Tumor Pathol 2014 March 19 in print Fouladi M et al J Neurooncol 2013 114 173-9 Killela PJ et al Oncotarget 2013 Oct 16 in print Mascaro Cordeiro B et al Childs Nerv Syst 2014 Apr 3 in print. 

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